Roy Soumya S, Appleby Kate M, Fear Elizabeth J, Duckett Simon B
Centre for Hyperpolarisation in Magnetic Resonance (CHyM), Department of Chemistry, University of York , Heslington, York YO10 5DD, United Kingdom.
J Phys Chem Lett. 2018 Mar 1;9(5):1112-1117. doi: 10.1021/acs.jpclett.7b03026. Epub 2018 Feb 19.
Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)(bis-diphenylphosphinopropane)] by displacing OTf to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding P signal was 105 ± 8 times larger than expected, which equated to an 8 h reduction in total scan time for an equivalent signal-to-noise ratio under normal acquisition conditions. Hence, p-H derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed, we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrates that are not amenable to the original SABRE method.
通过可逆交换进行信号放大（SABRE）用于开启对氢（p-H）的潜在单重态自旋序，以便它能够使底物（sub = 烟酰胺、烟酸酯、烟酸、嘧啶和吡嗪）超极化。然后底物通过取代OTf与[Pt(OTf)(双二苯基膦基丙烷)]可逆反应，形成[Pt(OTf)(sub)(双二苯基膦基丙烷)]OTf。当底物具有可及的单重态或长寿命塞曼极化时，这些金属配合物的磷核磁共振信号被证明得到增强。对于吡嗪，相应的磷信号比预期大105±8倍，这相当于在正常采集条件下，对于等效信噪比，总扫描时间减少了8小时。因此，源自p-H的自旋序通过合适的极化载体（sub）成功地传递到第二种金属配合物中。当充分发展时，我们预计这条涉及第二种催化剂的途径能够成功地使许多不适用于原始SABRE方法的底物超极化。
