Suchi T, Lennert K, Tu L Y, Kikuchi M, Sato E, Stansfeld A G, Feller A C
Department of Pathology, Aichi Cancer Center Hospital, Nagoya, Japan.
J Clin Pathol. 1987 Sep;40(9):995-1015. doi: 10.1136/jcp.40.9.995.
Based on the results of histological and immunohistochemical observations of a large number of peripheral T cell lymphomas from China, England, Germany and Japan, histological and cytological morphology were correlated with immunophenotype, aetiological association with HTLV-1, and clinical behaviour to produce a working classification of the T cell lymphomas. This classification, based mainly on cytological criteria, divides the peripheral T cell lymphomas into tumours of low grade and high grade malignancy. Adult T cell lymphoma/leukaemia (ATLL) is caused by HTLV-1 and belongs chiefly to the high grade category. Some tumours are characterised by an admixture of other cells (epithelioid cells, follicular dendritic cells, etc) and structures (high endothelial venules, follicles), which may indicate the secretion of lymphokines by the tumour cells. Clear cells seem to be specific for T cell lymphomas and may occur in various types of peripheral T cell lymphoma.
基于对来自中国、英国、德国和日本的大量外周T细胞淋巴瘤的组织学和免疫组化观察结果，将组织学和细胞学形态与免疫表型、与人类嗜T淋巴细胞病毒1型（HTLV-1）的病因学关联以及临床行为相关联，从而得出T细胞淋巴瘤的实用分类。该分类主要基于细胞学标准，将外周T细胞淋巴瘤分为低度恶性和高度恶性肿瘤。成人T细胞淋巴瘤/白血病（ATLL）由HTLV-1引起，主要属于高度恶性类别。一些肿瘤的特征是伴有其他细胞（上皮样细胞、滤泡树突状细胞等）和结构（高内皮小静脉、滤泡）的混合，这可能表明肿瘤细胞分泌淋巴因子。透明细胞似乎是T细胞淋巴瘤所特有的，可能出现在各种类型的外周T细胞淋巴瘤中。
