Vartak S, George K C, Singh B B
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Center, Trombay, Bombay, India.
Anticancer Res. 1993 May-Jun;13(3):727-9.
Local hyperthermia at 41-43 degrees C for 40 min prior to transplantation of a fibrosarcoma reduced its growth on the heated as well as the unheated contralateral legs of mice. The growth retardation was most pronounced in the unheated leg at 16 days interval between hyperthermia and tumor cell inoculation and was noticeable even at 22 days while in the heated leg it disappeared by the time. Inhibition of tumor growth was also independent of temperature and of the heating time at 43 degrees C. These results thus indicate that local hyperthermia induces both direct and abscopal antitumor effects which may probably be the result of a systemic effect of hyperthermia in the host animal.
在移植纤维肉瘤前，将小鼠的腿部在41-43摄氏度下进行40分钟的局部热疗，可减少纤维肉瘤在受热腿部以及未受热的对侧腿部的生长。在热疗与肿瘤细胞接种间隔16天时，未受热腿部的生长迟缓最为明显，即使在22天时仍可观察到，而在受热腿部，这种现象此时已消失。肿瘤生长的抑制也与温度以及43摄氏度下的加热时间无关。因此，这些结果表明局部热疗可诱导直接和远隔抗肿瘤效应，这可能是热疗在宿主动物体内产生全身效应的结果。
