Adekunle Isiaka Ayofe, Imafidon Christian Eseigbe, Oladele Ayowole Abraham, Ayoka Abiodun Oladele
Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Pathophysiology. 2018 Jun;25(2):101-115. doi: 10.1016/j.pathophys.2018.02.001. Epub 2018 Feb 7.
Cyclosporine (CYA), a common immuno-suppressant drug that is used in organ transplants, is associated with nephrotoxic effects. Scientific exploration of natural products of plant origin should be considered; especially, in a world with increasing prevalence of kidney diseases. Effects of ginger polyphenols (GP) in Wistar rats with CYA-induced perturbations in electrolyte balance and kidney function was determined. Fifty Wistar rats were recruited for this study such that graded doses of GP were administered following CYA-induced kidney injury and comparisons were made against control and toxic groups at p < 0.05. Distilled water, CYA (50 mg/kg p.o. for 10 days) and GP (100, 200 and 400 mg/kg p.o. for 21 days) were administered to the rats at 0.2 ml/100 g. CYA administration induced kidney injury as characterized by significant deleterious alterations in plasma and urine levels of creatinine, urea, Na and K electrolyte balance as well as creatinine clearance. Also, there was a significant derangement in feeding pattern and relative kidney weight. Using GSH and SOD as antioxidant indicators, there was significant disturbance of the anti-oxidant system while histopathological results showed evidence of interstitial vacuolations with atrophic glomeruli. These conditions were significantly attenuated (p < 0.05) following administration of graded doses of GP. It was, therefore, concluded that GP could potentially be a therapeutic choice for patients with CYA-induced kidney injury.
环孢素（CYA）是一种用于器官移植的常见免疫抑制药物，具有肾毒性作用。应该考虑对植物源天然产物进行科学探索；特别是在肾脏疾病患病率不断上升的世界中。本研究测定了生姜多酚（GP）对环孢素诱导的Wistar大鼠电解质平衡和肾功能紊乱的影响。本研究招募了50只Wistar大鼠，在环孢素诱导肾损伤后给予不同剂量的GP，并与对照组和中毒组进行比较，p<0.05。以0.2 ml/100 g的剂量给大鼠灌胃蒸馏水、环孢素（50 mg/kg口服，持续10天）和生姜多酚（100、200和400 mg/kg口服，持续21天）。环孢素给药导致肾损伤，表现为血浆和尿液中的肌酐、尿素、钠和钾电解质平衡以及肌酐清除率出现显著有害变化。此外，摄食模式和相对肾重量也出现了显著紊乱。以谷胱甘肽（GSH）和超氧化物歧化酶（SOD）作为抗氧化指标，抗氧化系统受到显著干扰，而组织病理学结果显示存在间质空泡化和肾小球萎缩的证据。给予不同剂量的生姜多酚后，这些情况得到显著改善（p<0.05）。因此，得出结论，生姜多酚可能是环孢素诱导肾损伤患者的一种治疗选择。
