MSC-exosome：一种用于皮肤再生的新型细胞游离治疗方法。

MSC-exosome: A novel cell-free therapy for cutaneous regeneration.

机构信息

Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

出版信息

Cytotherapy. 2018 Mar;20(3):291-301. doi: 10.1016/j.jcyt.2017.11.002. Epub 2018 Feb 9.

DOI:10.1016/j.jcyt.2017.11.002

PMID:29434006

Abstract

Cutaneous regeneration is a dynamic and complex process that requires a series of coordinated interactions involving epidermal cells, dermal cells, growth factors, the extracellular matrix (ECM), nerves and blood vessels at a damaged site. Mesenchymal stromal cells (MSCs) have been reported to participate in all afore-mentioned stages. Exosomes are one of the key secretory products of MSCs, resembling the effect of parental MSCs. They can shuttle various proteins, messenger RNA (mRNA) and microRNAs (miRNAs) to modulate the activity of recipient cells, and play important roles in cutaneous wound healing. Compared with MSCs, exosomes are more convenient to store and transport. Moreover, they avoid many risks associated with cell transplantation. Therefore, MSC-exosome-mediated therapy may be more safe and efficient. In this review, we summarize the latest studies and observations on the role of MSC-exosome in the acute and chronic wound model and provide a comprehensive understanding of the role of exosomes in wound healing. This review can assist investigators in exploring new therapeutic strategies for enhancing the efficacy of MSC-exosome for cutaneous repair and regeneration.

摘要

皮肤再生是一个动态而复杂的过程，需要一系列涉及表皮细胞、真皮细胞、生长因子、细胞外基质（ECM）、损伤部位的神经和血管的协调相互作用。间充质基质细胞（MSCs）已被报道参与所有上述阶段。外泌体是 MSCs 的主要分泌产物之一，类似于亲本 MSCs 的作用。它们可以传递各种蛋白质、信使 RNA（mRNA）和 microRNAs（miRNAs）来调节受体细胞的活性，并在皮肤伤口愈合中发挥重要作用。与 MSCs 相比，外泌体更便于储存和运输。此外，它们避免了与细胞移植相关的许多风险。因此，MSC-外泌体介导的治疗可能更安全、更有效。在这篇综述中，我们总结了 MSCs-外泌体在急性和慢性伤口模型中的作用的最新研究和观察结果，并提供了对外泌体在伤口愈合中作用的全面理解。这篇综述可以帮助研究人员探索新的治疗策略，以提高 MSC-外泌体在皮肤修复和再生中的疗效。