Eshraghian Ahad, Nikeghbalian Saman, Geramizadeh Bita, Malek-Hosseini Seyed Ali
Gastroenterohepatoloy Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
United European Gastroenterol J. 2018 Feb;6(1):97-103. doi: 10.1177/2050640617707863. Epub 2017 Apr 25.
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) has not been well recognized yet.
This study aimed to investigate the association between serum magnesium concentration and NAFLD.
Study participants were healthy individuals who had undergone liver biopsies between January 2012 and August 2015 as a routine pre-transplant check-up before living donor liver transplantation. Liver biopsy specimens were evaluated by an expert pathologist regarding presence of hepatic steatosis and steatohepatitis. Serum magnesium concentration was measured and compared in those with normal liver biopsy and those with steatosis and steatohepatitis.
A total of 226 individuals were included. Eighty-two individuals (36.2%) had hepatic steatosis and 22 (9.7%) individuals had steatohepatitis and steatosis in their liver histology. Lower serum magnesium concentration was independently associated with hepatic steatosis (OR: 0.059; 95% CI: 0.011-0.325, = 0.001). Serum magnesium concentration was independently associated with steatohepatitis compared to those without steatohepatitis (1.80 ± 0.48 mg/dl and 2.18 ± 0.31 mg/dl) (OR: 0.11; 95% CI: 0.02-0.41, = 0.001). Serum magnesium concentration was significantly lower in individuals with steatohepatitis (1.80 ± 0.48 mg/dl) compared to individuals without steatosis (2.23 ± 0.31 mg/dl, < 0.001) and individuals with only steatosis (2.07 ± 0.29 mg/dl, = 0.017).
Serum magnesium concentration is independently associated with hepatic steatosis and steatohepatitis in our study population.
非酒精性脂肪性肝病（NAFLD）的发病机制尚未得到充分认识。
本研究旨在探讨血清镁浓度与NAFLD之间的关联。
研究参与者为2012年1月至2015年8月期间作为活体肝移植术前常规检查接受肝活检的健康个体。由专业病理学家对肝活检标本进行肝脂肪变性和脂肪性肝炎的评估。测量并比较肝活检正常者与有脂肪变性和脂肪性肝炎者的血清镁浓度。
共纳入226例个体。82例（36.2%）有肝脂肪变性，22例（9.7%）在肝脏组织学检查中有脂肪性肝炎和脂肪变性。较低的血清镁浓度与肝脂肪变性独立相关（比值比：0.059；95%置信区间：0.011 - 0.325，P = 0.001）。与无脂肪性肝炎者相比，血清镁浓度与脂肪性肝炎独立相关（分别为1.80±0.48mg/dl和2.18±0.31mg/dl）（比值比：0.11；95%置信区间：0.02 - 0.41，P = 0.001）。与无脂肪变性者（2.23±0.31mg/dl，P < 0.001）和仅有脂肪变性者（2.07±0.29mg/dl，P = 0.017）相比，脂肪性肝炎患者的血清镁浓度显著降低。
在我们的研究人群中，血清镁浓度与肝脂肪变性和脂肪性肝炎独立相关。
