从简单青霉中分离出的新型青霉素衍生物。
New penicillide derivatives isolated from Penicillium simplicissimum.
作者信息
Komai Shin-Ichirou, Hosoe Tomoo, Itabashi Takeshi, Nozawa Koohei, Yaguchi Takashi, Fukushima Kazutaka, Kawai Ken-Ichi
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan.
出版信息
J Nat Med. 2006 Jul;60(3):185-190. doi: 10.1007/s11418-005-0028-9. Epub 2006 Apr 14.
Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.
从简单青霉IFM 53375的提取物中分离出两种新的青霉环肽衍生物，即仲青霉环肽A（3）和B（4），同时还分离出青霉环肽（1）、紫菌素A（2）、链格孢菌素（5）和脱氢链格孢菌素（6），后者是该真菌的抗真菌物质。通过光谱研究以及与青霉环肽（1）的化学关联确定了3和4的绝对结构。通过化学方法确定了紫菌素A（2）的绝对构型。
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