蠕孢霉素A和B，来自蠕形青霉的两种新型代谢产物。
Vermixocins A and B, two novel metabolites from Penicillium vermiculatum.
作者信息
Proksa B, Uhrín D, Adamcová J, Fuska J
机构信息
Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
出版信息
J Antibiot (Tokyo). 1992 Aug;45(8):1268-72. doi: 10.7164/antibiotics.45.1268.
PMID:1399847
Abstract
Vermixocins A and B, 3-(1'-hydroxy-3'-methylbutyl)- and 3-(1'-acetoxy-3'-methylbutyl)-11-hydroxy-4-methoxy-9-methyl-5H,7H- dibenzo[c,f][1,5]dioxocin-5-one, respectively, were isolated from the mycelium of Penicillium vermiculatum. Both metabolites showed cytotoxic effects on lympholeukemia cells P388.
摘要
分别从蠕形青霉的菌丝体中分离出了蛭霉素A和B，即3-(1'-羟基-3'-甲基丁基)-11-羟基-4-甲氧基-9-甲基-5H,7H-二苯并[c,f][1,5]二氧杂环己二烯-5-酮和3-(1'-乙酰氧基-3'-甲基丁基)-11-羟基-4-甲氧基-9-甲基-5H,7H-二苯并[c,f][1,5]二氧杂环己二烯-5-酮。这两种代谢产物对淋巴细胞白血病细胞P388均显示出细胞毒性作用。
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