Ozawa Tomohiro, Yamamoto Jynji, Yamagishi Takashi, Yamazaki Noriyuki, Nishizawa Makoto
Kyosei Pharmaceutical Co. Ltd., 3-1-1 Megumino-Kita, Eniwa, 061-1374, Japan.
Sakai Chemical Industries Co. Ltd., 1330-1 Matsugaoka-nakamachi, Kawachinagano, 586-0006, Japan.
J Nat Med. 2006 Jul;60(3):236-239. doi: 10.1007/s11418-006-0046-2. Epub 2006 May 11.
Two fucoidans have been isolated from the holdfast of cultivated Laminaira japonica. One (L-fucoidan) is rich in fucose and sulfate; the other (GA-fucoidan) is rich in uronate. L-fucoidan was found in the fronds of L. japonica (cultivated and wild), L. angustata, and Kjellmaniella crassifolia whereas GA-fucoidan was not detected in these fronds and may be a fucoidan specific to the holdfast. These two fucoidans were proved to have anti-tumor activity against Adenocarcinoma 755-transplanted mice by i.p. and p.o. administration.
从养殖海带的固着器中分离出了两种岩藻聚糖。一种（L-岩藻聚糖）富含岩藻糖和硫酸盐；另一种（GA-岩藻聚糖）富含糖醛酸。在养殖和野生的海带、狭叶海带以及厚叶石莼的叶片中发现了L-岩藻聚糖，而在这些叶片中未检测到GA-岩藻聚糖，GA-岩藻聚糖可能是固着器特有的岩藻聚糖。通过腹腔注射和口服给药，证明这两种岩藻聚糖对腺癌755移植小鼠具有抗肿瘤活性。
