Or Chris, Sabrosa Almyr S, Sorour Osama, Arya Malvika, Waheed Nadia
New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
Institute Ophthalmology Rio de Janeiro/Hospital da Gamboa, Rio de Janeiro, Brazil.
Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):46-51. doi: 10.22608/APO.201812. Epub 2018 Feb 13.
As ischemia remains a key prognostic factor in the management of various diseases including diabetic retinopathy, an increasing amount of research has been dedicated to its quantification as a potential biomarker. Advancements in the quantification of retinal ischemia have been made with the imaging modalities of fluorescein angiography (FA), ultra-widefield imaging (UWF), and optical coherence tomography angiography (OCTA), with each imaging modality offering certain benefits over the others. FA remains the gold standard in assessing the extent of ischemia. UWF imaging has allowed for the assessment of peripheral ischemia via FA. It is, however, OCTA that offers the best visualization of retinal vasculature with its noninvasive depth-resolved imaging and therefore has the potential to become a mainstay in the assessment of retinal ischemia. The primary purpose of this article is to review the use of FA, UWF, and OCTA to quantify retinal ischemia and the various methods described in the literature by which this is achieved.
由于缺血仍然是包括糖尿病视网膜病变在内的各种疾病管理中的关键预后因素，越来越多的研究致力于将其量化作为一种潜在的生物标志物。利用荧光素血管造影（FA）、超广角成像（UWF）和光学相干断层扫描血管造影（OCTA）等成像方式，在视网膜缺血量化方面取得了进展，每种成像方式都比其他方式具有一定优势。FA仍然是评估缺血程度的金标准。UWF成像能够通过FA评估周边缺血情况。然而，OCTA凭借其无创的深度分辨成像，能提供视网膜血管系统的最佳可视化效果，因此有潜力成为评估视网膜缺血的主要手段。本文的主要目的是综述FA、UWF和OCTA在量化视网膜缺血方面的应用，以及文献中描述的实现这一目标的各种方法。
