McCain H W, Lamster I B, Bilotta J
Int J Immunopharmacol. 1986;8(4):443-6. doi: 10.1016/0192-0561(86)90130-x.
beta-endorphin (10(-7) M) induced suppressor cell activity in human peripheral blood lymphocyte cultures comparable to that of concanavalin A (Con A) (60 micrograms/ml). beta-endorphin and Con A, when used together during the induction portion of the suppressor assays, displayed synergistic activity. In contrast, glycyl-L-glutamine, the carboxy terminal dipeptide of beta-endorphin, inhibited development of Con A induced suppressor activity. It appears that the previously reported suppressive effects of beta-endorphin on immune function may be achieved by activation of specific suppressor T cell populations.
β-内啡肽（10⁻⁷M）在人外周血淋巴细胞培养物中诱导的抑制细胞活性与伴刀豆球蛋白A（Con A）（60微克/毫升）相当。在抑制试验的诱导阶段，β-内啡肽和Con A一起使用时表现出协同活性。相比之下，β-内啡肽的羧基末端二肽甘氨酰-L-谷氨酰胺抑制Con A诱导的抑制活性的发展。看来，先前报道的β-内啡肽对免疫功能的抑制作用可能是通过激活特定的抑制性T细胞群体来实现的。
