Smyth D G, Parish D C, Normanton J R, Wolstencroft J H
Life Sci. 1983;33 Suppl 1:575-8. doi: 10.1016/0024-3205(83)90568-4.
Glycylglutamine, the C-terminal dipeptide of beta-endorphin, has previously been shown to be present in porcine pituitary. Evidence is given that this dipeptide occurs in ovine brain stem where its concentration was shown to be similar to that of the complementary fragments of beta-endorphin determined by chromatography and radioimmunoassay. Using the technique of microiontophoresis an inhibitory activity of the dipeptide was demonstrated on neurones located in the reticular formation of rat brain stem.
甘氨酰谷氨酰胺是β-内啡肽的C末端二肽，此前已证实在猪垂体中存在。有证据表明，这种二肽存在于羊脑干中，通过色谱法和放射免疫测定法显示其浓度与β-内啡肽的互补片段相似。使用微离子透入技术证明了该二肽对位于大鼠脑干网状结构中的神经元具有抑制活性。
