Materials Science Program, University of Montana, Missoula, MT 59812, USA; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA; Department of Chemistry and Biochemistry, University of Montana, Missoula, MT 59812, USA.
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center, Winston-Salem, NC, 27101, USA; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center at Wake Forest Baptist Medical, Medical Center Boulevard, Winston-Salem, NC 27157, USA; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Matrix Biol. 2019 May;78-79:337-345. doi: 10.1016/j.matbio.2018.02.010. Epub 2018 Feb 10.
Hyaluronan is a ubiquitous constituent of mammalian extracellular matrices and, because of its excellent intrinsic biocompatibility and chemical modification versatility, has been widely employed in a multitude of biomedical applications. In this article, we will survey the approaches used to tailor hyaluronan to specific needs of tissue engineering, regenerative and reconstructive medicine and overall biomedical research. We will also describe recent examples of applications in these broader areas, such as 3D cell culture, bioprinting, organoid biofabrication, and precision medicine that are facilitated by the use of hyaluronan as a biomaterial.
透明质酸是哺乳动物细胞外基质的一种普遍成分，由于其出色的内在生物相容性和化学修饰多功能性，已广泛应用于多种生物医学应用中。在本文中，我们将调查用于根据组织工程、再生和修复医学以及整体生物医学研究的具体需求定制透明质酸的方法。我们还将描述在这些更广泛的领域中的最新应用实例，例如 3D 细胞培养、生物打印、类器官生物制造和精准医学，这些应用都得益于透明质酸作为生物材料的使用。
