Katayama Haruna, Matsumoto Takeshi, Wada Hideo, Fujimoto Naoki, Toyoda Junki, Abe Yasunori, Ohishi Kohshi, Yamashita Yoshiki, Ikejiri Makoto, Habe Koji, Katayama Naoyuki
1 Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
2 Department of Ketsueki-Gyouko, Ogikubo hospital, Suginami, Tokyo, Japan.
Clin Appl Thromb Hemost. 2018 Oct;24(7):1170-1176. doi: 10.1177/1076029618757344. Epub 2018 Feb 13.
The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest for the height of acceleration peak. The peak time of acceleration, velocity, and ½ fibrin formation, and the width of acceleration and velocity were significantly long and the height of acceleration was significantly low in patients with hemophilia. The height of velocity was significantly low in patients with hemophilia with inhibitor. There were no significant differences in the APTT waveform between patients with hemophilia and patients with LA, but the peak of acceleration and ½ fibrin formation were significantly longer and the height of acceleration and velocity were significantly lower in patients with hemophilia with inhibitor than in the patients with LA. Wave changes in the APTT were observed in all 22 patients positive for LA, while a biphasic waveform was observed in patients with hemophilia with FVIII activity <10.0%. The APTT waveform is useful for the analysis of hemostatic abnormalities in patients with hemophilia.
近年来，已经评估了活化部分凝血活酶时间（APTT）波形在各种疾病中的作用。对血友病患者和狼疮抗凝物（LA）阳性患者的APTT波形进行了检查。加速峰高度与FVIII活性的相关性最高。血友病患者的加速峰时间、速度、1/2纤维蛋白形成时间以及加速和速度宽度显著延长，加速高度显著降低。有抑制剂的血友病患者的速度高度显著降低。血友病患者和LA患者之间的APTT波形没有显著差异，但有抑制剂的血友病患者的加速峰和1/2纤维蛋白形成时间显著更长，加速和速度高度显著低于LA患者。在所有22例LA阳性患者中均观察到APTT波形变化，而FVIII活性<10.0%的血友病患者观察到双相波形。APTT波形有助于分析血友病患者的止血异常情况。
