Liu Wangyu, Lin Shan, Cai Qiaoyan, Zhang Ling, Shen Aling, Chen Youqin, Chu Jianfeng, Peng Jun
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou, Fujian 350122, China.
Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou, Fujian 350122, China.
Evid Based Complement Alternat Med. 2017;2017:1576328. doi: 10.1155/2017/1576328. Epub 2017 Dec 26.
Qingxuan Jiangya Decoction (QXJYD) is a traditional Chinese medicine commonly used in the clinical treatment of hypertension. Earlier studies had shown that QXJYD could inhibit the elevation of blood pressure in spontaneously hypertensive rats (SHRs) and prevent remodeling of arterial vessels. This study examines the therapeutic efficacy of QXJYD against elevated blood pressure using the SHR model, as well as the mechanisms behind its antihypertensive activity and protection against renal fibrosis. The results showed that QXJYD significantly attenuated the increase in blood pressure in SHRs and mitigated the development of renal interstitial fibrosis. In addition, QXJYD also robustly decreased the excess accumulation of extracellular matrix and attenuated the elevated expression of MMPs. The antihypertensive effects and renal protection of QXJYD were determined to be strongly associated with inhibition of TGF-1/Smad signaling pathway.
清眩降压汤（QXJYD）是一种常用于高血压临床治疗的中药。早期研究表明，清眩降压汤可抑制自发性高血压大鼠（SHRs）血压升高，并预防动脉血管重塑。本研究使用SHR模型研究清眩降压汤对血压升高的治疗效果，以及其降压活性和预防肾纤维化的作用机制。结果表明，清眩降压汤显著减轻了SHRs血压的升高，并减轻了肾间质纤维化的发展。此外，清眩降压汤还显著减少了细胞外基质的过度积累，并减弱了基质金属蛋白酶（MMPs）的高表达。清眩降压汤的降压作用和肾脏保护作用被确定与抑制转化生长因子-1/信号转导和转录激活因子（TGF-1/Smad）信号通路密切相关。
