Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Biometals. 2018 Jun;31(3):321-330. doi: 10.1007/s10534-018-0082-x. Epub 2018 Feb 13.
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle.
肠出血性大肠杆菌（EHEC）O157：H7 是一种人畜共患病病原体，可导致人类食源性疾病，从水样腹泻到血性腹泻和严重出血性结肠炎、肾衰竭和溶血尿毒综合征。牛是 E. coli O157：H7 传播给人类的最重要来源，它们在没有表现出临床症状的情况下在胃肠道中携带这种细菌。预防牛源 E. coli O157：H7 感染可以降低公共卫生风险。然而，目前尚无针对 E. coli O157：H7 感染的特定治疗方法，也没有疫苗或治疗剂可完全预防牛源 E. coli O157：H7 感染。本文概述了使用牛乳铁蛋白根除反刍动物肠出血性 E. coli O157：H7 的最新研究数据。本文深入了解了牛乳铁蛋白对牛源 E. coli O157：H7 感染的抗菌和免疫调节作用。
