Goto T, Abe K, Tsunoda K, Seino M, Yasujima M, Imai Y, Chiba S, Sato M, Haruyama T, Omata K
Tohoku J Exp Med. 1985 Apr;145(4):403-11. doi: 10.1620/tjem.145.403.
To assess the role of inactive renin in hypertensive patients, active, inactive and total renin concentrations (ARC, IRC and TRC) were measured in 37 patients with hypertension of various etiologies. Inactive renin was activated by trypsin and renin concentration was measured using an excess of sheep substrate. Mean values of ARC, IRC, TRC and active renin ratio (AR ratio = ARC/TRC) were higher in 6 cases of renovascular hypertension, and lower in 6 cases of primary aldosteronism and 1 case of idiopathic hyperaldosteronism, when compared with 59 cases of normal subjects. Between ARC and IRC, a slightly positive correlation was observed. Moreover, between ARC and TRC as well as between ARC and AR ratio, close positive correlations were observed. Exceptionally, in a case of juxtaglomerular cell tumor, AR ratio was low in spite of the extremely high value of ARC. Our data suggest that the increase in circulating active renin is due to both the enhancement of the release of renin from the kidney and the increase in the activation of inactive renin, and vice versa.
为评估无活性肾素在高血压患者中的作用，我们对37例不同病因的高血压患者测定了活性肾素、无活性肾素及总肾素浓度（ARC、IRC和TRC）。无活性肾素用胰蛋白酶激活，肾素浓度采用过量的绵羊底物进行测定。与59例正常受试者相比，6例肾血管性高血压患者的ARC、IRC、TRC平均值及活性肾素比率（AR比率=ARC/TRC）较高，6例原发性醛固酮增多症患者及1例特发性醛固酮增多症患者的上述指标较低。ARC与IRC之间存在轻微正相关。此外，ARC与TRC之间以及ARC与AR比率之间均存在密切正相关。例外的是，在1例肾小球旁细胞瘤患者中，尽管ARC值极高，但AR比率却很低。我们的数据表明，循环中活性肾素的增加是由于肾素从肾脏释放的增强以及无活性肾素激活的增加，反之亦然。
