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使用功能性近红外光谱(NIRS)神经成像的神经成像现场方法:用于研究撒哈拉以南非洲农村地区儿童的全球发育情况。

Neuroimaging Field Methods Using Functional Near Infrared Spectroscopy (NIRS) Neuroimaging to Study Global Child Development: Rural Sub-Saharan Africa.

作者信息

Jasińska Kaja K, Guei Sosthène

机构信息

Linguistics and Cognitive Science Department, University of Delaware; Haskins Laboratories;

Centre de Recherche et d'Action pour la Paix.

出版信息

J Vis Exp. 2018 Feb 2(132):57165. doi: 10.3791/57165.

DOI:10.3791/57165
PMID:29443053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5912326/
Abstract

Portable neuroimaging approaches provide new advances to the study of brain function and brain development with previously inaccessible populations and in remote locations. This paper shows the development of field functional Near Infrared Spectroscopy (fNIRS) imaging to the study of child language, reading, and cognitive development in a rural village setting of Côte d'Ivoire. Innovation in methods and the development of culturally appropriate neuroimaging protocols allow a first-time look into the brain's development and children's learning outcomes in understudied environments. This paper demonstrates protocols for transporting and setting up a mobile laboratory, discusses considerations for field versus laboratory neuroimaging, and presents a guide for developing neuroimaging consent procedures and building meaningful long-term collaborations with local government and science partners. Portable neuroimaging methods can be used to study complex child development contexts, including the impact of significant poverty and adversity on brain development. The protocol presented here has been developed for use in Côte d'Ivoire, the world's primary source of cocoa, and where reports of child labor in the cocoa sector are common. Yet, little is known about the impact of child labor on brain development and learning. Field neuroimaging methods have the potential to yield new insights into such urgent issues, and the development of children globally.

摘要

便携式神经成像方法为脑功能和脑发育研究带来了新进展,能够研究以前难以接触到的人群以及偏远地区的情况。本文展示了现场功能近红外光谱(fNIRS)成像技术在科特迪瓦一个乡村环境中对儿童语言、阅读和认知发展研究的应用。方法上的创新以及符合文化背景的神经成像方案的开发,使人们首次得以了解在研究较少的环境中大脑的发育情况以及儿童的学习成果。本文展示了运输和搭建移动实验室的方案,讨论了现场神经成像与实验室神经成像的注意事项,并提供了一份开发神经成像同意程序以及与当地政府和科学合作伙伴建立有意义的长期合作关系的指南。便携式神经成像方法可用于研究复杂的儿童发育情况,包括严重贫困和逆境对大脑发育的影响。这里介绍的方案是为在世界主要可可生产国科特迪瓦使用而制定的,该国可可行业童工现象屡见不鲜。然而,对于童工对大脑发育和学习的影响却知之甚少。现场神经成像方法有可能为这些紧迫问题以及全球儿童的发育情况带来新的见解。

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