Department of Chemistry (S & H), Vel Tech Multi Tech, Chennai, 600062, India.
Department of Chemistry, B.S Abdur Rahman University, Vandalur, Chennai, 600048, India.
Sci Rep. 2018 Feb 14;8(1):3054. doi: 10.1038/s41598-018-21366-1.
A Schiff base ligand (SBL), N, N-bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio. H NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL. A novel series of lanthanide (i.e., praseodymium (Pr), erbium (Er), and ytterbium (Yb))-based SBL metal complexes was successfully synthesized, and their functional groups were elaborately demonstrated using UV-visible, Fourier transform infrared (FT-IR), and fluorescence spectroscopy analyses. FT-IR spectral studies revealed that SBL behaved as a bidentate ligand and it was structured with metal ions by the two azomethine nitrogens. The synthesized SBL-based metal complexes were elaborately performed for cytotoxicity activity versus Vero, human breast cancer (MCF7), and cervical (HeLa) anticancer cell lines.
一种席夫碱配体（SBL），N，N-双（蒽-9-亚甲基）吡啶-2,3-二胺，通过使用 1:2 比例的 2,6-二氨基吡啶和蒽-9-甲醛缩合合成。1H NMR 光谱证实了 SBL 中不涉及芳香羧酸质子的观察。成功合成了一系列新型镧系（即镨（Pr）、铒（Er）和镱（Yb））基于 SBL 的金属配合物，并使用紫外可见、傅里叶变换红外（FT-IR）和荧光光谱分析详细说明了它们的官能团。FT-IR 光谱研究表明，SBL 作为双齿配体存在，通过两个亚氨基氮与金属离子形成结构。对基于 SBL 的合成金属配合物进行了详细的细胞毒性活性测试，以评估其对非洲绿猴肾（Vero）、人乳腺癌（MCF7）和宫颈（HeLa）癌细胞系的作用。
