Mortimer P S, Dawber R P, Gales M A, Moore R A
Br J Dermatol. 1986 Sep;115(3):263-8. doi: 10.1111/j.1365-2133.1986.tb05740.x.
In order to examine whether anti-androgen therapy was effective in hidradenitis suppurativa (HS), ethinyloestradiol 50 micrograms/cyproterone acetate 50 mg in a reverse sequential regimen was compared with ethinyloestradiol 50 micrograms/norgestrel 500 micrograms (Eugynon 50) in 24 female patients. Both treatments produced substantial improvement in disease activity. Seven patients cleared and have remained free of disease for 18 months, five patients improved, four remained unchanged, while two deteriorated. Cyproterone acetate was not clinically significantly more effective than E50, and both gave a similar reduction in free androgen index. Anti-androgen therapy appears to be beneficial in the treatment of hidradenitis suppurativa.
为了研究抗雄激素疗法对化脓性汗腺炎（HS）是否有效，将24例女性患者中采用反向序贯疗法的50微克乙炔雌二醇/50毫克醋酸环丙孕酮与50微克乙炔雌二醇/500微克炔诺孕酮（复方炔诺酮片50）进行了比较。两种治疗方法均使疾病活动度有显著改善。7例患者病情清除且18个月来未再发病，5例患者病情改善，4例无变化，2例病情恶化。醋酸环丙孕酮在临床上并不比复方炔诺酮片50更有效，两者使游离雄激素指数下降程度相似。抗雄激素疗法似乎对化脓性汗腺炎的治疗有益。
