Sawers R S, Randall V A, Ebling F J
Br J Dermatol. 1986 Sep;115(3):269-74. doi: 10.1111/j.1365-2133.1986.tb05741.x.
The effects of combined treatment with the antiandrogen, cyproterone acetate, and ethinyl oestradiol on four women with long-standing hidradenitis suppurativa have been investigated. The condition was controlled successfully in all patients with 100 mg/day cyproterone acetate using the reversed sequential regimen; lowering the antiandrogen to 50 mg/day caused deterioration. Before treatment, plasma testosterone levels were within the normal range, but plasma androstenedione values were raised and sex hormone binding globulin levels were low. On treatment, the androstenedione concentration fell and sex hormone-binding globulin values were raised. However, since these levels were unaltered by reducing the antiandrogen dosage, the main action of the therapy is probably that of the antiandrogen within the target cells.
已对四名患有长期化脓性汗腺炎的女性采用抗雄激素醋酸环丙孕酮和炔雌醇联合治疗的效果进行了研究。使用反向序贯疗法，每日100毫克醋酸环丙孕酮可使所有患者的病情得到成功控制；将抗雄激素剂量降至每日50毫克会导致病情恶化。治疗前，血浆睾酮水平在正常范围内，但血浆雄烯二酮值升高，性激素结合球蛋白水平较低。治疗期间，雄烯二酮浓度下降，性激素结合球蛋白值升高。然而，由于降低抗雄激素剂量并未改变这些水平，该疗法的主要作用可能是靶细胞内抗雄激素的作用。
