Rosen Paul S, Qari Maha, Froum Stuart J, Dibart Serge, Chou L Lee
Int J Periodontics Restorative Dent. 2018 Mar/Apr;38(2):261-267. doi: 10.11607/prd.3203.
This in vitro pilot study was performed to determine whether a treatment algorithm including mechanical debridement, followed by air powder abrasion with glycine, followed by citric acid conditioning with vigorous flushing of the surface with sterile water after each step, is capable of decontaminating an infected implant surface. A total of 14 dental implants that were deemed hopeless due to advanced peri-implantitis were extracted. Of these, 6 implants served as tests and had their exposed surfaces treated with the decontamination protocol, 6 served as untreated controls, and 2 were mechanically treated only, followed by rubbing the surface with sterile saline. All implants were placed in culture with human osteoprogenitor cells for 72 hours, and evaluation was performed using scanning electron microscopy. The 6 test implants all demonstrated attachment and proliferation of the normal human osteoprogenitor cells on their prior exposed and decontaminated surfaces. All of the untreated control and the mechanically debrided, sterile water-treated implants failed to demonstrate this same success. The results suggest that this protocol can decontaminate an implant surface affected by peri-implantitis. Further studies are warranted to determine if this technique would demonstrate similar success over a greater number of implants and whether this outcome may occur in humans.
本体外初步研究旨在确定一种治疗方案，即先进行机械清创，然后用甘氨酸进行气粉磨蚀，每一步之后用无菌水强力冲洗表面，再用柠檬酸进行表面处理，是否能够对受感染的种植体表面进行去污。共拔除了14颗因重度种植体周围炎而被判定无可挽救的牙种植体。其中，6颗种植体作为试验组，其暴露表面采用去污方案进行处理；6颗作为未处理的对照组；2颗仅进行机械处理，然后用无菌盐水擦拭表面。所有种植体均与人类骨祖细胞一起培养72小时，并使用扫描电子显微镜进行评估。6颗试验种植体在其先前暴露和去污的表面均显示出正常人类骨祖细胞的附着和增殖。所有未处理的对照种植体以及仅进行机械清创、无菌水处理的种植体均未取得同样的成功。结果表明，该方案可对受种植体周围炎影响的种植体表面进行去污。有必要进一步研究以确定该技术在更多种植体上是否能取得类似的成功，以及这种结果是否会在人体中出现。
