Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
BMC Public Health. 2018 Feb 15;18(1):260. doi: 10.1186/s12889-018-5160-z.
The final meeting of the EXPOsOMICS project "Final Policy Workshop and Stakeholder Consultation" took place 28-29 March 2017 to present the main results of the project and discuss their implications both for future research and for regulatory and policy activities. This paper summarizes presentations and discussions at the meeting related with the main results and advances in exposome research achieved through the EXPOsOMICS project; on other parallel research initiatives on the study of the exposome in Europe and in the United States and their complementarity to EXPOsOMICS; lessons learned from these early studies on the exposome and how they may shape the future of research on environmental exposure assessment; and finally the broader implications of exposome research for risk assessment and policy development on environmental exposures. The main results of EXPOsOMICS in relation to studies of the external exposome and internal exposome in relation to both air pollution and water contaminants were presented as well as new technologies for environmental health research (adductomics) and advances in statistical methods. Although exposome research strengthens the scientific basis for policy development, there is a need in terms of showing added value for public health to: improve communication of research results to non-scientific audiences; target research to the broader landscape of societal challenges; and draw applicable conclusions. Priorities for future work include the development and standardization of methodologies and technologies for assessing the external and internal exposome, improved data sharing and integration, and the demonstration of the added value of exposome science over conventional approaches in answering priority policy questions.
EXPOsOMICS 项目“最终政策研讨会和利益相关者磋商”的最后一次会议于 2017 年 3 月 28 日至 29 日举行，旨在展示项目的主要成果，并讨论这些成果对未来研究以及监管和政策活动的影响。本文总结了会议上与通过 EXPOsOMICS 项目在暴露组学研究方面取得的主要成果和进展相关的演示和讨论；与欧洲和美国其他关于暴露组学研究的平行研究计划及其与 EXPOsOMICS 的互补性；从这些早期暴露组学研究中吸取的经验教训，以及它们如何塑造未来环境暴露评估研究的未来；最后是暴露组学研究对环境暴露风险评估和政策制定的更广泛影响。会议还介绍了 EXPOsOMICS 与空气污染和水污染相关的外部暴露组学和内部暴露组学研究的主要结果，以及环境健康研究的新技术（加合物组学）和统计方法的进展。尽管暴露组学研究为政策制定提供了更坚实的科学基础，但在向非科学界受众传达研究结果、将研究重点放在更广泛的社会挑战领域以及得出可应用的结论方面，仍存在一些需要改进的地方。未来工作的重点包括开发和标准化评估外部和内部暴露组学的方法和技术、改善数据共享和整合，并展示暴露组学科学在回答优先政策问题方面相对于传统方法的附加价值。
