Shaffer Rachel M, Smith Marissa N, Faustman Elaine M
Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington , Seattle, Washington, USA.
Institute for Risk Analysis and Risk Communication, University of Washington , Seattle, Washington, USA.
Environ Health Perspect. 2017 Aug 7;125(8):085003. doi: 10.1289/EHP1250.
Exposome-related efforts aim to document the totality of human exposures across the lifecourse. This field has advanced rapidly in recent years but lacks practical application to risk assessment, particularly for children's health.
Our objective was to apply the exposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapshots (LEnS). Case studies are presented to illustrate the value of the framework.
The LEnS framework encourages organization of exposome studies based on windows of susceptibility for particular target organ systems. Such analyses will provide information regarding cumulative impacts during specific critical periods of the life course. A logical extension of this framework is that regulatory standards should analyze exposure information by target organ, rather than for a single chemical only or multiple chemicals grouped solely by mechanism of action.
The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children's health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. https://doi.org/10.1289/EHP1250.
与暴露组相关的研究旨在记录人类在整个生命历程中的全部暴露情况。近年来，该领域发展迅速，但在风险评估中的实际应用尚显不足，尤其是在儿童健康风险评估方面。
我们的目标是通过引入生命阶段暴露组快照（LEnS）概念，将暴露组应用于儿童健康风险评估。本文通过案例研究来说明该框架的价值。
LEnS框架鼓励基于特定靶器官系统的易感性窗口来组织暴露组研究。此类分析将提供有关生命历程中特定关键时期累积影响的信息。该框架的一个合理延伸是，监管标准应按靶器官分析暴露信息，而不是仅针对单一化学物质或仅按作用机制对多种化学物质进行分组分析。
LEnS概念是对暴露组的一种切实改进，它考虑了靶器官系统在特定易感性窗口期间的总暴露情况。将LEnS框架应用于风险评估和监管将通过加强对敏感发育器官系统的保护来改善儿童健康保护，这些器官系统对终身健康和福祉至关重要。https://doi.org/10.1289/EHP1250
