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Transcriptomic and metabolomic associations with exposures to air pollutants among young adults with childhood asthma history.转录组学和代谢组学与儿童哮喘病史的年轻成年人暴露于空气污染物的关联。
Environ Pollut. 2022 Apr 15;299:118903. doi: 10.1016/j.envpol.2022.118903. Epub 2022 Jan 25.
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Multi-omics analysis to reveal disorders of cell metabolism and integrin signaling pathways induced by PM.多组学分析揭示 PM 诱导的细胞代谢和整合素信号通路紊乱
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Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.204 个国家和地区 1990-2019 年 87 种风险因素的全球负担:2019 年全球疾病负担研究的系统分析。
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What is new in the exposome?外核组学有哪些新进展?
Environ Int. 2020 Oct;143:105887. doi: 10.1016/j.envint.2020.105887. Epub 2020 Jun 30.
6
Health Benefits of Air Pollution Reduction.减少空气污染的健康益处。
Ann Am Thorac Soc. 2019 Dec;16(12):1478-1487. doi: 10.1513/AnnalsATS.201907-538CME.
7
Effects of fossil fuel and total anthropogenic emission removal on public health and climate.化石燃料和人为总排放清除对公共健康和气候的影响。
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7192-7197. doi: 10.1073/pnas.1819989116. Epub 2019 Mar 25.
8
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9
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空气污染:从全球健康到个体风险因素——日常临床实践中是否到了考虑它的时候?

Air Pollution from Global Health to Individual Risk Factor-Is It Time for in Everyday Clinical Practice?

机构信息

University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), San Giovanni Bosco Hub Hospital, Department of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy.

UNESCO Chair in Sustainable Development and Territory Management, University of Turin, 10124 Turin, Italy.

出版信息

Int J Environ Res Public Health. 2022 Aug 4;19(15):9595. doi: 10.3390/ijerph19159595.

DOI:10.3390/ijerph19159595
PMID:35954950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9367743/
Abstract

While the link between cardiovascular and respiratory conditions and air pollution is well-known, recent studies provided a growing body of evidence that polluted air, particularly air with high levels of particulate matter with a diameter smaller than 2.5 micrometers (PM 2.5), can have a range of negative impacts on health, both in terms of mortality and morbidity. It is time to emphasize the role of environmental factors as contributory factors or determinants of both global and individual health levels, and to consider them together as a health priority, as enviropathies (meant as pathologies caused, triggered or worsened by environmental exposure). Bringing attention to harmful air pollution exposure has fostered population studies, which developed accurate quantification of environmental exposure in polluted regions, aiding our understanding of the dose-response relationship between pollutants and diseases. Those efforts have influenced local and global health policy strategies. Now we face the challenge of controlling environmental pollution and limiting individual exposure to prevent or avoid serious health risks. Is it time for enviropathies in everyday clinical practice?

摘要

虽然心血管和呼吸道疾病与空气污染之间的联系是众所周知的,但最近的研究提供了越来越多的证据表明,污染的空气,特别是直径小于 2.5 微米的细颗粒物(PM 2.5)含量较高的空气,会对健康产生一系列负面影响,无论是在死亡率还是发病率方面。现在是时候强调环境因素作为全球和个人健康水平的促成因素或决定因素的作用了,并将它们作为一个健康优先事项来考虑,因为环境病(意味着由环境暴露引起、引发或加重的疾病)。关注有害空气污染暴露促使人们开展了人群研究,这些研究对污染地区的环境暴露进行了准确的量化,帮助我们理解污染物与疾病之间的剂量-反应关系。这些努力影响了地方和全球卫生政策策略。现在,我们面临着控制环境污染和限制个人暴露以预防或避免严重健康风险的挑战。在日常临床实践中关注环境病的时机是否已经成熟?