Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea.
Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea; National Research Center for Dementia, Gwangju, South Korea.
Parkinsonism Relat Disord. 2018 May;50:42-47. doi: 10.1016/j.parkreldis.2018.02.016. Epub 2018 Feb 9.
Coffee consumption has an inverse association with the risk of Parkinson's disease (PD). The aim of this study was to investigate the association between coffee consumption and non-motor symptoms (NMSs) in patients with PD.
In this cross-sectional study, we included 196 early-stage, treatment-naïve PD patients. Coffee consumption history was obtained via semi-structured interviews. NMSs were assessed using the Non-Motor Symptom assessment scale (NMSS).
Of the 196 patients with PD, 136 (69.3%) were categorized as coffee drinkers and 60 (30.6%) were non-drinkers. Coffee drinkers were younger, predominantly male, were younger in age at symptom onset, had lower Unified Parkinson's Disease Rating Scale motor and Beck Depression Inventory scores, and higher Mini-Mental State Examination scores than non-coffee drinkers. After adjustment, coffee drinking was significantly inversely associated with the prevalence of lack of motivation, anhedonia, and lack of pleasure, which were less frequent in coffee drinkers. Total NMSS scores were lower in coffee drinkers than in non-drinkers (p = 0.047). In particular, coffee drinking was significantly associated with a reduced severity of the mood/cognition domain of NMSS (p = 0.003). After correcting for multiple testing, there were no significant differences in the prevalence of NMSs, but there were significant differences in the severity of NMSs between coffee drinkers and non-drinkers.
There is a negative association between coffee consumption and the severity of the mood/cognition domain of NMSS in patients with PD. Clinicians should consider the history of coffee consumption in the assessment of NMSs in PD.
咖啡的摄入与帕金森病（PD）的发病风险呈负相关。本研究旨在探讨咖啡摄入与 PD 患者非运动症状（NMSs）之间的关系。
在这项横断面研究中，我们纳入了 196 例初诊、未经治疗的 PD 患者。通过半结构式访谈获取咖啡摄入史。使用非运动症状评估量表（NMSS）评估 NMSs。
在 196 例 PD 患者中，136 例（69.3%）为咖啡饮用者，60 例（30.6%）为非饮用者。与非咖啡饮用者相比，咖啡饮用者更年轻、以男性为主，症状起始年龄更小，统一帕金森病评定量表运动评分和贝克抑郁量表评分更低，简易精神状态检查评分更高。调整后，咖啡摄入与缺乏动力、快感缺失和愉悦感缺乏的患病率呈显著负相关，咖啡饮用者中这些症状的发生率较低。咖啡饮用者的 NMSS 总分低于非饮用者（p=0.047）。特别是，咖啡摄入与 NMSS 情绪/认知域严重程度降低显著相关（p=0.003）。在进行多次检验校正后，两组 NMSs 的患病率无显著差异，但咖啡饮用者与非饮用者之间 NMSs 的严重程度存在显著差异。
咖啡摄入与 PD 患者 NMSS 情绪/认知域的严重程度呈负相关。临床医生在评估 PD 患者的 NMSs 时应考虑咖啡摄入史。
