咖啡摄入对新发帕金森病震颤严重程度的性别依赖性影响。
Gender-dependent effect of coffee consumption on tremor severity in de novo Parkinson's disease.
机构信息
Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea.
出版信息
BMC Neurol. 2019 Aug 14;19(1):194. doi: 10.1186/s12883-019-1427-y.
BACKGROUND
Coffee consumption represents a negative risk factor for Parkinson's disease (PD) and seems to affect PD motor symptoms. We aimed to investigate the association between coffee consumption and motor symptoms in de novo PD patients.
METHODS
In total, 284 patients with de novo PD were included in the current study. Motor and non-motor symptoms were evaluated using various scales. History of coffee consumption was obtained via a semi-structured interview.
RESULTS
In total, 204 patients were categorized as coffee drinkers and 80 as non-coffee drinkers. Coffee drinkers were predominantly male and had early symptom onset; in addition, they were younger, reported more years in formal education, and had better motor and non-motor scores than did non-coffee drinkers. After adjustments, coffee drinkers had lower tremor scores than did non-coffee drinkers, and coffee consumption was related to tremors in a dose-dependent manner. These relationships were statistically significant in case of rest tremor but not in case of action tremor. The dose-dependent relationship between coffee consumption and tremor severity was significant only in men. Non-motor symptom scores were not significantly different between coffee drinkers and non-coffee drinkers.
CONCLUSIONS
Coffee consumption and tremor severity are inversely related in male patients with de novo PD.
背景
咖啡消费代表了帕金森病（PD）的一个负面风险因素，并且似乎会影响 PD 的运动症状。我们旨在研究咖啡消费与新发 PD 患者运动症状之间的关联。
方法
本研究共纳入 284 例新发 PD 患者。使用各种量表评估运动和非运动症状。通过半结构化访谈获取咖啡消费史。
结果
共有 204 例患者被归类为咖啡饮用者，80 例为非咖啡饮用者。咖啡饮用者主要为男性，且发病较早；此外，他们更年轻，接受正规教育的年限更长，运动和非运动评分均优于非咖啡饮用者。调整后，咖啡饮用者的震颤评分低于非咖啡饮用者，且咖啡消费与震颤之间呈剂量依赖性关系。这种关系在静止性震颤中具有统计学意义，但在动作性震颤中无统计学意义。咖啡消费与震颤严重程度之间的剂量依赖性关系仅在男性中显著。咖啡饮用者和非咖啡饮用者的非运动症状评分无显著差异。
结论
在新发 PD 男性患者中，咖啡消费与震颤严重程度呈负相关。
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