Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.
National Biodiversity Future Center (NBFC), 90133 Palermo, Italy.
Nutrients. 2024 Apr 26;16(9):1298. doi: 10.3390/nu16091298.
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain.
蘑菇、植物、微藻和蓝藻中的天然产物因其预防或治疗潜力而受到广泛研究。在与年龄相关的疾病中，神经退行性疾病（如阿尔茨海默病和帕金森病）是一个全球性的健康和社会问题。由于多种病理机制与神经退行性变有关，针对神经退行性疾病的有前途的策略旨在针对多个过程。这些方法通常可以避免过早的细胞死亡和受损神经元功能的丧失。本综述重点关注几种源于天然来源的化合物的预防和治疗潜力，这些化合物可能因其神经保护作用而被开发利用。姜黄素、白藜芦醇、麦角硫因和藻蓝蛋白被作为成功方法的例子，特别关注改善它们向大脑递送的可能策略。
