a Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine , The University of Tokyo , Tokyo , Japan.
Autophagy. 2019 Jan;15(1):176-177. doi: 10.1080/15548627.2018.1532262. Epub 2018 Oct 13.
Mammalian autophagosomes possess the Qa-SNARE STX17 (syntaxin 17) for fusion with lysosomes. However, STX17 is not absolutely required for fusion because STX17 knockout cells partially retain autophagosome-lysosome fusion activity. We recently identified YKT6, an R-SNARE, as another autophagosomal SNARE protein that acts independently of STX17 in mammals. Here, we discuss the features and functions of autophagosomal SNARE proteins by comparing STX17 and YKT6. Abbreviations: SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; STX17, syntaxin 17.
哺乳动物的自噬体具有与溶酶体融合的 Qa-SNARE STX17（突触融合蛋白 17）。然而，STX17 并不是融合所必需的，因为 STX17 敲除细胞部分保留了自噬体-溶酶体融合活性。我们最近发现 YKT6，一种 R-SNARE，是哺乳动物中另一种独立于 STX17 的自噬体 SNARE 蛋白。在这里，我们通过比较 STX17 和 YKT6 来讨论自噬体 SNARE 蛋白的特征和功能。缩写：SNARE，可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体；STX17，突触融合蛋白 17。
