Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga, 520-2192, Japan.
Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Sci Rep. 2018 Feb 15;8(1):3132. doi: 10.1038/s41598-018-21445-3.
Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular constituents for the above properties, we performed a comprehensive transcriptome analysis of differently aged cells of mice by high-throughput sequencing and identified the genes selectively highly expressed in the young cells. These genes, collectively called as juvenility-associated genes (JAGs), show significant enrichments in the functions such as alternative splicing, phosphorylation and extracellular matrix (ECM). This implies the juvenescence might be achieved by these functions at the cell level. The JAG mutations are associated with progeria syndromes and growth disorders. Thus, the JAGs might organize the juvenile property of young animals and analysis of JAGs may provide scientific and therapeutic approaches toward treating the genetic diseases.
年轻人具有成年人所没有的独特特征。与成年人相比，幼年动物在生长、愈合、学习和可塑性方面表现出更高的活力。建立这些幼年特征的机制尚未完全了解。为了更好地理解上述特性的分子组成部分，我们通过高通量测序对不同年龄的小鼠细胞进行了全面的转录组分析，鉴定出在年轻细胞中选择性高表达的基因。这些基因，统称为“与年轻相关的基因”（JAGs），在选择性剪接、磷酸化和细胞外基质（ECM）等功能中表现出显著富集。这意味着细胞水平上的年轻可能是通过这些功能实现的。JAG 突变与早衰综合征和生长障碍有关。因此，JAGs 可能会组织年轻动物的年轻特性，对 JAGs 的分析可能会为治疗遗传疾病提供科学和治疗方法。
