致癌物处理过的仓鼠颊囊部分切除对后续肿瘤发展的影响。

Influence of partial excision of carcinogen treated hamster cheek pouch on subsequent tumour development.

作者信息

MacDonald D G, Shepherd D E, Critchlow H A

出版信息

Br J Oral Maxillofac Surg. 1986 Oct;24(5):342-8. doi: 10.1016/0266-4356(86)90019-7.

Abstract

Hamster cheek pouch was treated with carcinogen for 5 or 8 weeks. Part of the carcinogen treated area was excised and the lesion allowed to heal by secondary intention. At follow-up the biopsied pouches were compared with control pouches and potentiation of the development of carcinomas was seen. It is suggested that these results have relevance to the previously demonstrated tumour potentiating effect of cryosurgery in hamster cheek pouch, in that the important tumour potentiating influence may be regeneration involving dysplastic epithelium and not a function of cryosurgery per se.

摘要

将致癌物作用于仓鼠颊囊5周或8周。切除部分经致癌物处理的区域，让损伤通过二期愈合自行愈合。在随访时，将活检的颊囊与对照颊囊进行比较，发现癌的发生有增强现象。有人提出，这些结果与先前证明的冷冻手术对仓鼠颊囊的肿瘤促进作用有关，因为重要的肿瘤促进影响可能是涉及发育异常上皮的再生，而不是冷冻手术本身的作用。