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成年女性肠胃炎并发溶血尿毒综合征:病例报告。

Gastroenteritis in an adult female revealing hemolytic uremic syndrome: Case report.

机构信息

Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City 14050, Mexico.

出版信息

World J Gastroenterol. 2018 Feb 14;24(6):763-766. doi: 10.3748/wjg.v24.i6.763.

DOI:10.3748/wjg.v24.i6.763
PMID:29456415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5807679/
Abstract

Nowadays acute gastroenteritis infection caused by () O157:H7 is frequently associated with hemolytic uremic syndrome (HUS), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascular damage which manifested as arteriolar and capillary thrombosis with abnormalities in the endothelium and vessel walls. The major etiological agent of HUS is enterohemorragic () strain belonging to serotype O157:H7. The lack of papers about HUS associated to gastroenteritis lead us to report this case for explain the symptoms that are uncommon. Furthermore, this report provides some strategies to suspect and make an early diagnosis, besides treatment approach to improving outcomes and prognosis for patients with this disorder.

摘要

如今,由 () O157:H7 引起的急性肠胃炎感染常伴有溶血性尿毒症综合征 (HUS),其通常发生在常伴有血性腹泻的前驱期之后。腹痛伴有肾功能衰竭是发生这种疾病的可疑症状。其病理特征是血管损伤,表现为小动脉和毛细血管血栓形成,内皮和血管壁异常。HUS 的主要病原体是属于血清型 O157:H7 的肠出血性 () 菌株。由于缺乏与肠胃炎相关的 HUS 论文,我们报告了这个病例,以解释不常见的症状。此外,本报告还提供了一些策略来怀疑和早期诊断这种疾病,以及治疗方法来改善患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a52/5807679/b25395a6bc9f/WJG-24-763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a52/5807679/b25395a6bc9f/WJG-24-763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a52/5807679/b25395a6bc9f/WJG-24-763-g001.jpg

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本文引用的文献

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Shiga toxin-producing Escherichia coli: incidence and clinical features in a setting with complete screening of patients with suspected infective diarrhoea.产志贺毒素大肠埃希菌:在对疑似感染性腹泻患者进行全面筛查的环境中的发生率和临床特征。
Clin Microbiol Infect. 2018 Jun;24(6):635-639. doi: 10.1016/j.cmi.2017.10.002. Epub 2017 Oct 10.
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Estimating true incidence of O157 and non-O157 Shiga toxin-producing Escherichia coli illness in Germany based on notification data of haemolytic uraemic syndrome.基于溶血性尿毒综合征的报告数据估算德国O157和非O157产志贺毒素大肠杆菌疾病的真实发病率。
Epidemiol Infect. 2016 Nov;144(15):3305-3315. doi: 10.1017/S0950268816001436. Epub 2016 Jul 29.
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Endothelial cell control of thrombosis.
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Syndromes of thrombotic microangiopathy.血栓性微血管病的综合征。
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Sporadic bloody diarrhoea-associated thrombotic thrombocytopenic purpura-haemolytic uraemic syndrome: an adult and paediatric comparison.散发性血性腹泻相关的血栓性血小板减少性紫癜-溶血尿毒综合征:成人与儿童的比较
Br J Haematol. 2008 May;141(5):696-707. doi: 10.1111/j.1365-2141.2008.07116.x. Epub 2008 Apr 15.
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