Shen Li-Ling, Muo Chih-Hsin, Su Shan-Yu, Morisky Donald E
Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
Department of Public Health, China Medical University, Taichung 40402, Taiwan.
Evid Based Complement Alternat Med. 2017;2017:4082630. doi: 10.1155/2017/4082630. Epub 2017 Dec 31.
The Pap test diagnosed cervical dysplasia, which could recover to normal or progress to cervical cancer (CC), is an early stage of cell abnormality before CC. This case-control study analyzed the differences in the risk to develop CC between Chinese medicine (CM) users and nonusers among women who had ever been diagnosed as having cervical dysplasia. A total of 750 CC patients with a cervical dysplasia history were collected between 1998 and 2011 from National Health Insurance Research Database, and controls were women with cervical dysplasia history but did not develop CC. Adjusted odds ratio (aOR) for developing CC was assessed using multivariable logistic regression after adjusting for age, urbanization of residence, and occupation. The proportion of using CM among CC patients was lower than that among CC nonpatients, with an aOR of 0.8. By analyzing the relationship between CC development and the frequency of CM usage, the trend test revealed a significant decreasing trend for developing CC among high-frequency CM users. Moreover, the most frequently used single herb high-frequency was (Da-Huang). The usage of CM might be an effective complementary method to prevent uterine cervix from progressing to CC after cervical dysplasia has occurred.
巴氏试验可诊断出宫颈发育异常，这种情况可能恢复正常或发展为宫颈癌（CC），是宫颈癌发生前的细胞异常早期阶段。这项病例对照研究分析了曾被诊断为宫颈发育异常的女性中，使用中药（CM）者和未使用者患宫颈癌风险的差异。1998年至2011年期间，从国民健康保险研究数据库中收集了750例有宫颈发育异常病史的宫颈癌患者，对照组为有宫颈发育异常病史但未患宫颈癌的女性。在调整年龄、居住城市化程度和职业后，使用多变量逻辑回归评估患宫颈癌的调整优势比（aOR）。宫颈癌患者中使用中药的比例低于未患宫颈癌者，aOR为0.8。通过分析宫颈癌发生与中药使用频率之间的关系，趋势检验显示高频使用中药者患宫颈癌有显著下降趋势。此外，最常使用的单味高频中药是大黄。中药的使用可能是宫颈发育异常发生后预防子宫颈发展为宫颈癌的一种有效辅助方法。
