Mvondo Marie Alfrede, Minko Essono Stéphane, Bomba Tatsinkou Francis Désiré, Ateba Sylvin Benjamin, Njamen Dieudonné
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Evid Based Complement Alternat Med. 2017;2017:8563909. doi: 10.1155/2017/8563909. Epub 2017 Dec 31.
(Mimosaceae) was reported to have analgesic and antioxidant properties. The present study is aimed at investigating the effects of the root aqueous extract of (EA) on an experimental model of endometriosis. The study was performed in rats orally treated with EA at doses of 127.5, 255, and 510 mg/kg. Microgynon® 30 served as the reference substance. Estradiol valerate and oxytocin were used to induce dysmenorrhea. Endometrial implant levels of catalase and malondialdehyde (MDA) allowed estimating tissue oxidative status. Ovarian dynamic and rat sexual behavior were assessed through histological analysis of ovaries, uterus, and vagina. EA decreased dysmenorrhea at tested doses following a 7-day treatment ( < 0.001). Endometrial implant volume decreased following the three treatment periods ( < 0.05). Catalase activity ( < 0.001) and MDA level ( < 0.01) increased only following a 3-day treatment. EA also increased antral follicles, reduced luteinized unruptured follicle number ( < 0.001), and induced animals to be in the estrus phase. In conclusion, EA prevented the progress of endometriosis, reduced dysmenorrhea, promoted ovarian follicle growth, prevented anovulation, and stimulated the special period of rat sexual desire. These results suggest that could be a promising alternative option for the treatment of endometriosis.
据报道，含羞草科植物具有镇痛和抗氧化特性。本研究旨在探讨[植物名称]根水提取物（EA）对子宫内膜异位症实验模型的影响。该研究在口服给予剂量为127.5、255和510mg/kg的EA的大鼠中进行。复方炔诺酮片作为参比物质。戊酸雌二醇和缩宫素用于诱导痛经。通过检测过氧化氢酶和丙二醛（MDA）在子宫内膜植入物中的水平来评估组织氧化状态。通过对卵巢、子宫和阴道的组织学分析评估卵巢动态和大鼠性行为。经7天治疗后，EA在测试剂量下可减轻痛经（P<0.001）。三个治疗周期后，子宫内膜植入物体积减小（P<0.05）。仅在3天治疗后，过氧化氢酶活性增加（P<0.001），MDA水平增加（P<0.01）。EA还增加了窦状卵泡数量，减少了黄素化未破裂卵泡数量（P<0.001），并诱导动物进入发情期。总之，EA可阻止子宫内膜异位症的进展，减轻痛经，促进卵巢卵泡生长，防止无排卵，并刺激大鼠性欲的特殊时期。这些结果表明，[植物名称]可能是治疗子宫内膜异位症的一种有前景的替代选择。
