Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
Department of Occupational and Environmental Medicine, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
Contact Dermatitis. 2018 May;78(5):348-354. doi: 10.1111/cod.12962. Epub 2018 Feb 19.
An inverse relationship between disease severity and health-related quality of life (HR-QoL) in patients with hand eczema is well established, but modifying effects of demographic variables have been less well studied.
To identify the influence of metropolitan versus non-metropolitan residence on the relationship between disease severity and HR-QoL in patients with occupational hand eczema.
The city of Copenhagen and the rest of Zealand were defined as metropolitan and non-metropolitan areas, respectively. Participants were 773 persons with occupational hand eczema. A questionnaire on the severity of hand eczema and HR-QoL was sent to all participants.
The odds for reporting moderate to high severity of occupational hand eczema were significantly lower in the metropolitan population than in the non-metropolitan population [odds ratio (OR): 0.42; 95%CI: 0.23-0.75], whereas low dermatology-related quality of life was more prevalent in metropolitan than in non-metropolitan patients (OR: 1.31; 95%CI: 0.83-2.05), indicating that hand eczema had a more pronounced negative effect in metropolitan patients, in spite of less severe eczema.
Our data indicate that area of residence has a modifying effect on the relationship between disease severity and HR-QoL, with a more negative impact on HR-QoL in metropolitan than in non-metropolitan areas. This information is important with respect to fully appreciating the burden of occupational hand eczema.
手部湿疹患者的疾病严重程度与健康相关生活质量（HR-QoL）之间呈负相关，这已得到充分证实，但人口统计学变量的影响尚未得到充分研究。
确定居住在大都市与非大都市对职业性手部湿疹患者疾病严重程度与 HR-QoL 之间关系的影响。
哥本哈根市和西兰岛其他地区分别定义为大都市和非大都市地区。共有 773 名职业性手部湿疹患者参与了研究。向所有参与者发送了一份关于手部湿疹严重程度和 HR-QoL 的问卷。
与非大都市人群相比，大都市人群报告中重度职业性手部湿疹的几率显著降低（优势比[OR]：0.42；95%可信区间[CI]：0.23-0.75），而大都市患者的皮肤病相关生活质量较低的比例更高（OR：1.31；95%CI：0.83-2.05），表明尽管手部湿疹的严重程度较低，但大都市患者的湿疹对 HR-QoL 的负面影响更为明显。
我们的数据表明，居住地对疾病严重程度与 HR-QoL 之间的关系具有修饰作用，与非大都市地区相比，大都市地区对 HR-QoL 的负面影响更大。这些信息对于全面了解职业性手部湿疹的负担非常重要。
