Cavaillès Matthieu, Bornet Aurélien, Jaurand Xavier, Vuichoud Basile, Baudouin David, Baudin Mathieu, Veyre Laurent, Bodenhausen Geoffrey, Dumez Jean-Nicolas, Jannin Sami, Copéret Christophe, Thieuleux Chloé
Institut de Chimie de Lyon, Laboratory C2P2 UMR 5265-CNRS, Université de Lyon 1-CPE Lyon, CPE Lyon, 43 Bd du 11 Novembre 1918, 69616, Villeurbanne, France.
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7453-7457. doi: 10.1002/anie.201801009. Epub 2018 Mar 15.
Tailoring the physical features and the porous network architecture of silica-based hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization (d-DNP). High polarization values up to P( H)=99 % were reached for samples impregnated with a mixture of H O/D O and loaded in a 6.7 T polarizer at temperatures around 1.2 K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices, which provide hyperpolarized solutions free of any-potentially toxic-additives (radicals and glass-forming agents). The hyperpolarized solutions can be expelled from the porous solids, filtered, and rapidly transferred either to a nuclear magnetic resonance (NMR) spectrometer or to a magnetic resonance imaging (MRI) system.
定制含有TEMPO自由基的二氧化硅基超极化固体（称为HYPSO，即混合极化固体）的物理特性和多孔网络结构，实现了前所未有的溶解动态核极化（d-DNP）性能。对于浸渍有H₂O/D₂O混合物并在约1.2 K温度下加载到6.7 T偏振器中的样品，达到了高达P(H)=99%的高极化值。这些HYPSO材料将均相DNP配方的最佳性能与固体极化基质的优势相结合，提供不含任何潜在有毒添加剂（自由基和玻璃形成剂）的超极化溶液。超极化溶液可以从多孔固体中排出、过滤，并迅速转移到核磁共振（NMR）光谱仪或磁共振成像（MRI）系统中。
