Schmid K W, Synoracki S, Dralle H, Wittekind C
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
West German Cancer Centre Essen (WTZ), Essen, Germany.
Pathologe. 2019 Jun;40(Suppl 1):18-24. doi: 10.1007/s00292-018-0418-x.
In the 8th edition of the TNM classification of thyroid carcinomas, which was introduced in 2017, carcinomas with minimal extrathyroidal extension are no longer mentioned, which might cause problems. These tumors were explicitly categorized in previous TNM classifications (5-7th editions). Studies on the prognostic relevance of minimal extrathyroidal extension have shown conflicting results. Moreover, the vast majority of these studies retrospectively analyzed only subgroups of thyroid carcinomas (e.g. differentiated thyroid carcinoma, papillary thyroid carcinoma). The proposed subcategorization of the current TNM classification (8th edition) ensures the continuity of the parameter minimal extrathyroidal extension within the TNM categorization of thyroid carcinomas and also offers the possibility to prospectively analyze in a standardized manner the potential biological relevance of minimal extrathyroidal extension in relation to tumor categories (T/pT category).
在2017年推出的第8版甲状腺癌TNM分类中，未再提及甲状腺外扩展极小的癌，这可能会引发问题。这些肿瘤在之前的TNM分类（第5 - 7版）中被明确分类。关于甲状腺外扩展极小的预后相关性研究结果相互矛盾。此外，这些研究绝大多数仅对甲状腺癌亚组（如分化型甲状腺癌、乳头状甲状腺癌）进行了回顾性分析。当前TNM分类（第8版）提议的亚分类确保了甲状腺癌TNM分类中甲状腺外扩展极小这一参数的连续性，并且还提供了以前瞻性标准化方式分析甲状腺外扩展极小相对于肿瘤类别（T/pT类别）的潜在生物学相关性的可能性。
