Department of Endocrine Disorders and Bone Metabolism, Chair of Endocrinology, Medical University of Lodz, Lodz, Poland, Zeligowskiego 7/9, 90-752 Lodz, Poland; Outpatient Clinic of Endocrinology, Regional Center of Menopause and Osteoporosis, Military Teaching Hospital in Lodz, Poland, Wierzbowa 38, 90-245 Lodz, Poland.
Endokrynol Pol. 2018;69(2):142-149. doi: 10.5603/EP.a2018.0008. Epub 2018 Feb 21.
Osteoporosis is a serious medical and socioeconomic problem of the 21st century. Mechanical load is a key regulator which controls bone formation and remodelling, with participation of osteocytes. Sclerostin is produced and released by mature osteocytes into bone surface, where it inhibits the conveyance of osteoblast proliferation and differentiation activating signals from mesenchymal cells, thus suppressing new bone formation. The goal of the study was an evaluation of the effects of a 12-week physical training programme on the levels of bone turnover markers [Sclerostin, Osteocalcin (OC), C-terminal telopeptide of type I collagen (β-CTX)] in blood serum of women with osteopenia.
MATERIALS & METHODS: The study included 50 women of the Regional Menopause and Osteoporosis Centre of the WAM Teaching Hospital, at the age of 50-75 years with the diagnosis of osteopenia, obtained on the basis of hip and/or lumbar spine densitometry (T-score from -1.0 to -2.5 SD). During the initial 12 weeks (between point 1 and 2), the patients maintained their previous, normal level of physical activity. During subsequent 12 weeks (between point 2 and 3), a programme of exercise was implemented. The programme included the interval training on a bicycle ergometer, three times a week for 36 minutes. During the entire study duration, all the patients received a supplementation of calcium (500 mg) and vit. D3 (1800 IU) once daily. Serum levels of OC, alkaline phosphatase (ALP), β-CTX and sclerostin were assayed at 3 time points.
After the course of the exercise cycle, the OC concentration was increased, sclerostin levels decreased, while no statistical differences were observed in β-CTX levels vs. the period of physical inactivity. No correlations were found between sclerostin level changes and osteocalcin level changes during the training time, because of too small groups. Neither statistically significant were the differences in alkaline phosphatase, calcium and phosphorus levels.
The obtained results emphasise the role of physical training as an effective stimulation method of bone formation processes in women with osteopenia. Sclerostin can be a marker of physical activity. < /p > < p >.
骨质疏松症是 21 世纪严重的医学和社会经济问题。机械负荷是控制骨形成和重塑的关键调节因子，成骨细胞参与其中。骨硬化蛋白由成熟的成骨细胞产生并释放到骨表面，在那里它抑制成骨细胞增殖和分化激活信号从间充质细胞传递，从而抑制新骨形成。本研究的目的是评估为期 12 周的体育训练计划对骨质疏松症女性血清骨转换标志物[骨硬化蛋白、骨钙素（OC）、I 型胶原 C 端肽（β-CTX）]水平的影响。
本研究纳入了 50 名年龄在 50-75 岁的妇女，她们在 WAM 教学医院的区域绝经和骨质疏松症中心被诊断为骨质疏松症，其依据是髋关节和/或腰椎骨密度（T 评分从-1.0 到-2.5 SD）。在最初的 12 周（第 1 点和第 2 点之间），患者保持以前的正常体力活动水平。在随后的 12 周（第 2 点和第 3 点之间），实施了运动方案。该方案包括每周三次在自行车测力计上进行间歇训练，每次 36 分钟。在整个研究期间，所有患者每天补充钙（500 毫克）和维生素 D3（1800 IU）。在 3 个时间点检测 OC、碱性磷酸酶（ALP）、β-CTX 和骨硬化蛋白的血清水平。
在运动周期结束后，OC 浓度增加，骨硬化蛋白水平降低，而β-CTX 水平与不活动期间相比无统计学差异。在训练期间，由于样本量太小，未发现骨硬化蛋白水平变化与骨钙素水平变化之间存在相关性。碱性磷酸酶、钙和磷水平也无统计学差异。
研究结果强调了体育锻炼作为一种有效刺激骨形成过程的方法在骨质疏松症妇女中的作用。骨硬化蛋白可以作为身体活动的标志物。
