a Biochemistry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.
b Department of Physical Education and Sport Sciences, University of Kurdistan, Iran.
Appl Physiol Nutr Metab. 2019 Mar;44(3):282-287. doi: 10.1139/apnm-2018-0197. Epub 2018 Aug 27.
Exercise-induced weight loss can occur for several reasons, including changes in circulatory levels of appetite-regulating hormones. The purpose of this study was to compare the effect of various training programs on fasting serum levels of acylated ghrelin, peptide YY 3-36 (PYY) and glucagon-like peptide-1 (GLP-1), as well as weight and body mass index (BMI) changes. Forty-four overweight men were randomly assigned into 4 groups of 11 individuals, which included (i) endurance group (3 sets of 10 min with 80%-90% of maximum heart rate), (ii) resistance group (4 sets of 8 repetitions with 80% of 1-repetition maximum), (iii) concurrent group (combination of programs of endurance and resistance groups in an alternate manner), and (iv) control group. Training protocols were conducted for 12 weeks for 3 sessions per week. Results showed that all 3 types of training programs resulted in weight loss (p = 0.000, p = 0.000, and p = 0.036 for resistance, concurrent, and endurance groups, respectively), BMI reduction (p = 0.000, p = 0.000, and p = 0.034), decreased serum acylated ghrelin (p = 0.000, p = 0.000, and p = 0.004), and increased PYY hormone levels (p = 0.028, p = 0.035, and p = 0.036). However, the effect of resistance training on these changes was more pronounced. Moreover, none of the exercise programs had any effect on serum levels of GLP-1. In addition, there was a significant positive correlation between weight (p = 0.003) and BMI (p = 0.009) changes with ghrelin while a negative correlation was observed between weight (p = 0.003) and BMI (p = 0.03) changes with PYY. The findings suggest that regular exercise training, in particular resistance training, is likely to reduce body weight and improve body composition of overweight inactive people by suppressing orexigenic hormones and stimulating the anorexigenic hormones.
运动引起的体重减轻可能有几个原因，包括食欲调节激素循环水平的变化。本研究的目的是比较各种训练方案对空腹血清酰化 ghrelin、肽 YY 3-36（PYY）和胰高血糖素样肽-1（GLP-1）水平以及体重和体重指数（BMI）变化的影响。44 名超重男性被随机分为 4 组，每组 11 人，包括（i）耐力组（3 组，每组 10 分钟，心率为最大心率的 80%-90%），（ii）阻力组（4 组，每组 8 次重复，最大重复次数的 80%），（iii）联合组（耐力和阻力组以交替方式组合），和（iv）对照组。训练方案每周进行 3 次，共 12 周。结果表明，所有 3 种训练方案均导致体重减轻（阻力组、联合组和耐力组分别为 p = 0.000、p = 0.000 和 p = 0.036）、BMI 降低（p = 0.000、p = 0.000 和 p = 0.034）、血清酰化 ghrelin 减少（p = 0.000、p = 0.000 和 p = 0.004）和 PYY 激素水平升高（p = 0.028、p = 0.035 和 p = 0.036）。然而，阻力训练对这些变化的影响更为明显。此外，运动方案均未对 GLP-1 血清水平产生任何影响。此外，ghrelin 与体重（p = 0.003）和 BMI（p = 0.009）变化之间存在显著正相关，而 PYY 与体重（p = 0.003）和 BMI（p = 0.03）变化之间存在负相关。研究结果表明，定期运动训练，特别是阻力训练，通过抑制食欲激素和刺激厌食激素，可能会减轻超重不活跃人群的体重并改善其身体成分。
