Hamblin Michael R, Nelson Scott T, Strahan Justin R
1 Department of Dermatology, Wellman Center for Photomedicine , Massachusetts General Hospital, Boston, Massachusetts.
2 Joovv Inc., Crystal, Minnesota.
Photomed Laser Surg. 2018 May;36(5):241-245. doi: 10.1089/pho.2017.4401. Epub 2018 Feb 21.
Photobiomodulation (PBM) therapy is a rapidly growing approach to stimulate healing, reduce pain, increase athletic performance, and improve general wellness.
Applying PBM therapy over the site of a tumor has been considered to be a contraindication. However, since another growing use of PBM therapy is to mitigate the side effects of cancer therapy, this short review seeks to critically examine the evidence of whether PBM therapy is beneficial or harmful in cancer patients.
PubMed and Google Scholar were searched.
Although there are a few articles suggesting that PBM therapy can be detrimental in animal models of tumors, there are also many articles that suggest the opposite and that light can directly damage the tumor, can potentiate other cancer therapies, and can stimulate the host immune system. Moreover, there are two clinical trials showing increased survival in cancer patients who received PBM therapy.
PBM therapy may have benefits in cancer patients and should be further investigated.
光生物调节（PBM）疗法是一种迅速发展的促进愈合、减轻疼痛、提高运动表现和改善整体健康状况的方法。
在肿瘤部位应用PBM疗法一直被视为禁忌。然而，由于PBM疗法另一个日益增长的用途是减轻癌症治疗的副作用，本综述旨在批判性地审视PBM疗法对癌症患者有益还是有害的证据。
检索了PubMed和谷歌学术。
尽管有几篇文章表明PBM疗法在肿瘤动物模型中可能有害，但也有许多文章得出相反结论，即光可直接损伤肿瘤、增强其他癌症治疗效果并刺激宿主免疫系统。此外，有两项临床试验表明接受PBM疗法的癌症患者生存率提高。
PBM疗法可能对癌症患者有益，应进一步研究。
