芳基糠醛衍生物的抗病毒活性。
Antiviral activity of aryl-furfurane derivatives.
作者信息
Votyakov V I, Shashikhina M N, Izergina E A, Zhavrid S V, Stashkevich N P, Oleinik A F
出版信息
Acta Virol. 1984 Jan;28(1):33-8.
PMID:6143495
Abstract
Of 27 aryl-furfurane derivatives (AFD) studied, 13 compounds were found to have antiviral activity against ECHO 6, herpes simplex, vaccinia, and influenza A/Hong Kong/1/68 (H3N2) viruses, the highest inhibition being observed with ECHO 6 virus. The maximum tolerated concentrations (MaTC) of AFD inhibited the macromolecular syntheses in ECHO 6 virus-infected cell cultures.
摘要
在研究的27种芳基糠醛衍生物（AFD）中，发现13种化合物对艾柯病毒6型、单纯疱疹病毒、牛痘病毒和甲型流感病毒/香港/1/68（H3N2）具有抗病毒活性，其中对艾柯病毒6型的抑制作用最为显著。AFD的最大耐受浓度（MaTC）可抑制艾柯病毒6型感染的细胞培养物中的大分子合成。
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