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塞内加尔5岁以下儿童急性呼吸道感染的病毒和细菌病因

Viral and Bacterial Etiologies of Acute Respiratory Infections Among Children Under 5 Years in Senegal.

作者信息

Assane Dieng, Makhtar Camara, Abdoulaye Diop, Amary Fall, Djibril Boiro, Amadou Diop, Niokhor Diouf Jean Baptiste, Amadou Diop, Cheikh Loucoubar, Ndongo Dia, Mbayame Niang, Lamine Fall, Bouh Boye Cheikh Saad

机构信息

Laboratory of Bacteriology and Virology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal.

Medical Virology Unit, Institute Pasteur, Dakar, Senegal.

出版信息

Microbiol Insights. 2018 Feb 13;11:1178636118758651. doi: 10.1177/1178636118758651. eCollection 2018.

Abstract

Acute respiratory infections (ARIs) are the leading cause of infectious disease-related morbidity, hospitalization, and morbidity among children worldwide. This study aimed to assess the viral and bacterial causes of ARI morbidity and mortality in children under 5 years in Senegal. Nasopharyngeal samples were collected from children under 5 years who had ARI. Viruses and bacteria were identified using multiplex real-time reverse transcription-polymerase chain reaction and conventional biochemical techniques, respectively. Adenovirus was the most prevalent virus (50%; n = 81), followed by influenza virus (45.68%, n = 74), rhinovirus (40.12%; n = 65), enterovirus (25.31%; n = 41), and respiratory syncytial virus (16.05%; n = 26), whereas (17%; n = 29), (15.43%; n = 25), and (8.02%; n = 13) were the most commonly isolated bacteria. Virus pathogens seem more likely to be more prevalent in our settings and were often associated with bacteria and (6%; 16) coinfection.

摘要

急性呼吸道感染(ARIs)是全球儿童感染性疾病相关发病、住院和死亡的主要原因。本研究旨在评估塞内加尔5岁以下儿童ARI发病和死亡的病毒及细菌病因。从患有ARI的5岁以下儿童中采集鼻咽样本。分别使用多重实时逆转录-聚合酶链反应和传统生化技术鉴定病毒和细菌。腺病毒是最常见的病毒(50%;n = 81),其次是流感病毒(45.68%,n = 74)、鼻病毒(40.12%;n = 65)、肠道病毒(25.31%;n = 41)和呼吸道合胞病毒(16.05%;n = 26),而[此处原文缺失细菌名称](17%;n = 29)、[此处原文缺失细菌名称](15.43%;n = 25)和[此处原文缺失细菌名称](8.02%;n = 13)是最常分离出的细菌。病毒病原体在我们的研究环境中似乎更常见,且常与细菌以及[此处原文缺失细菌名称](6%;16例)合并感染有关。

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