Gerber Daniel, Forster Catherine S, Hsieh Michael
Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC, 20007, USA.
Children's National Health System, 111 Michigan Avenue NW Suite M4800, Washington, DC, 20010, USA.
Curr Urol Rep. 2018 Feb 22;19(1):13. doi: 10.1007/s11934-018-0763-6.
In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient.
Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile. Early studies aimed to identify the resident bacterial species and demonstrate the efficacy of sequencing and enhanced quantitative urine culture. More recently, research has sought to elucidate the association between the microbiome and urologic disease, as well as to demonstrate effects of manipulation of the microbiome on various urologic pathologies. With an improved appreciation for the impact of the urinary microbiome on urologic disease, researchers have begun to explore the impact of these resident bacteria in pediatric urology.
在本综述中，我们重点介绍微生物群对影响儿科患者的泌尿系统疾病的作用。
已表明泌尿微生物群的紊乱与多种影响儿童的泌尿系统疾病有关，即尿路感染、膀胱过度活动症/急迫性尿失禁和尿路结石。最近，改进的培养和测序技术使得能够发现膀胱中存在大量且多样的微生物群，此前认为膀胱是无菌的。早期研究旨在鉴定常驻细菌种类，并证明测序和强化定量尿培养的功效。最近，研究试图阐明微生物群与泌尿系统疾病之间的关联，并证明微生物群操纵对各种泌尿系统病理的影响。随着对泌尿微生物群对泌尿系统疾病影响的认识不断提高，研究人员已开始探索这些常驻细菌在小儿泌尿外科中的影响。
