Scott Department of Urology, Baylor College of Medicine, 7200 Cambridge St. 10th Floor, Suite B, Office#A10157, Houston, TX, 77030, USA.
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Curr Urol Rep. 2022 Mar;23(3):47-56. doi: 10.1007/s11934-022-01088-8. Epub 2022 Feb 9.
The aim of this review is to explore the effect of the microbiome on urolithiasis and explore recent advances and challenges in microbiome research for urolithiasis.
Lack of standardization and shortcomings in study design for urinary microbiome research on urolithiasis has hampered the generalizability of results and weakened the impact of findings on clinical practice. Important study limitations include sample heterogenicity, specimen contamination, poor culture yields, and lack of shared datasets for meta-analysis. Contrary to traditional teaching, the genitourinary tract is not a sterile environment. This urinary microbiome may influence the pathogenesis of urolithiasis, although the specific mechanisms are still currently being explored. Successful investigation will depend on consistency in study design and analysis, as well as sharing data and protocols across institutions. Developing an understanding of the relationship between the urinary microbiome and urolithiasis may lead to novel approaches to mitigate stone risk.
本文旨在探讨微生物组对尿石症的影响，并探讨微生物组研究在尿石症领域的最新进展和挑战。
尿石症微生物组研究缺乏标准化和研究设计的缺陷，阻碍了研究结果的推广，并削弱了研究结果对临床实践的影响。重要的研究局限性包括样本异质性、标本污染、培养产量低以及缺乏用于荟萃分析的共享数据集。与传统观念相反，泌尿生殖道并不是一个无菌的环境。这种尿液微生物组可能会影响尿石症的发病机制，尽管具体机制仍在探索中。成功的研究取决于研究设计和分析的一致性，以及机构间的数据和方案共享。了解尿液微生物组与尿石症之间的关系可能会为降低结石风险提供新的方法。
