Ackerman A Lenore, Underhill David M
Division of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ann Transl Med. 2017 Jan;5(2):31. doi: 10.21037/atm.2016.12.69.
The mycobiome, defined as the fungal microbiota within a host environment, is an important but understudied component of the human microbial ecosystem. New culture-independent approaches to determine microbial diversity, such as next-generation sequencing methods, have discovered specific, characteristic, commensal fungal populations present in different body sites. These studies have also identified diverse patterns in fungal communities associated with various diseases. While alterations in urinary bacterial communities have been noted in disease states, a comprehensive description of the urinary mycobiome has been lacking. Early evidence suggests the urinary mycobiome is a diverse community with high intraindividual variability. In other disease systems, the mycobiome is thought to interact with other biomes and the host to play a role in organ homeostasis and pathology; further study will be needed to elucidate the role fungi play in bladder health and disease.
真菌微生物组被定义为宿主环境中的真菌微生物群，是人类微生物生态系统中一个重要但尚未得到充分研究的组成部分。新的用于确定微生物多样性的非培养方法，如下一代测序方法，已经发现了存在于不同身体部位的特定、特征性共生真菌种群。这些研究还确定了与各种疾病相关的真菌群落的不同模式。虽然在疾病状态下已注意到尿液细菌群落的改变，但对尿液真菌微生物组的全面描述一直缺乏。早期证据表明，尿液真菌微生物组是一个具有高个体内变异性的多样化群落。在其他疾病系统中，真菌微生物组被认为与其他生物群落和宿主相互作用，在器官稳态和病理学中发挥作用；需要进一步研究以阐明真菌在膀胱健康和疾病中所起的作用。
