Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
J Hum Nutr Diet. 2018 Aug;31(4):513-522. doi: 10.1111/jhn.12541. Epub 2018 Feb 22.
Micronutrient deficiency is a global health burden, especially among developing countries. The present cross-sectional study aimed to determine the prevalence of vitamin B deficiency in healthy Indian school-going adolescents, based on area of residence, sex and body mass index (BMI). Furthermore, the relationship of serum B concentration with dietary vitamin B intake and anthropometric indices was assessed among adolescents from rural and urban India.
A total of 2403 school-going adolescents (11-17 years) from National Capital Region and rural areas of Haryana, India were selected. Serum B concentrations were estimated using an electrochemiluminescence immunoassay. Dietary assessments were conducted on 65% of total participants (n = 1556) by two 24-h diet recalls.
The prevalence of vitamin B deficiency in the total study population was 32.4% (rural: 43.9% versus urban: 30.1%, P < 0.001; male: 34.4% versus female: 31.0%, P < 0.05; normal weight: 28.1%, versus overweight: 39.8%, versus obese: 51.2%, P < 0.001). More than half (51.2%) of obese adolescents were vitamin B deficient. On multiple linear regression analysis, serum B in rural adolescents was associated with age (β = -0.12, P < 0.05). Among urban adolescents, serum B was associated with BMI (β = -0.08, P < 0.05) and adjusted dietary vitamin B intake (β = 0.14, P < 0.001). Serum vitamin B levels were found to be lower in rural females (β = -0.12, P = 0.030) and urban males (β: 0.11, P < 0.001) compared to their respective contemporaries.
Vitamin B deficiency was higher among rural school-going adolescents. Boys had a higher B deficiency than girls. Inverse associations of serum B with adiposity indices were observed. Serum B levels were positively associated with dietary vitamin B intake.
微量营养素缺乏是全球健康负担，尤其是在发展中国家。本横断面研究旨在根据居住地区、性别和体重指数（BMI），确定健康印度在校青少年维生素 B 缺乏的流行率。此外，评估了来自印度农村和城市的青少年血清 B 浓度与膳食维生素 B 摄入量和人体测量指数的关系。
从印度首都地区和哈里亚纳邦农村地区选择了 2403 名 11-17 岁的在校青少年。使用电化学发光免疫测定法估计血清 B 浓度。通过两次 24 小时饮食回忆对总参与者的 65%（n=1556）进行了膳食评估。
在总研究人群中，维生素 B 缺乏的患病率为 32.4%（农村：43.9%，城市：30.1%，P<0.001；男性：34.4%，女性：31.0%，P<0.05；正常体重：28.1%，超重：39.8%，肥胖：51.2%，P<0.001）。超过一半（51.2%）的肥胖青少年维生素 B 缺乏。在多元线性回归分析中，农村青少年的血清 B 与年龄呈负相关（β=-0.12，P<0.05）。在城市青少年中，血清 B 与 BMI（β=-0.08，P<0.05）和调整后的膳食维生素 B 摄入量（β=0.14，P<0.001）呈负相关。与各自的同龄人相比，农村女性（β=-0.12，P=0.030）和城市男性（β：0.11，P<0.001）的血清维生素 B 水平较低。
农村在校青少年维生素 B 缺乏率较高。男孩的 B 缺乏症比女孩高。血清 B 与肥胖指数呈负相关。血清 B 水平与膳食维生素 B 摄入量呈正相关。
