• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Commentary: Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage.

作者信息

Matsoukas Ianis G

机构信息

Faculty of Health and Human Sciences, School of Sport and Biomedical Sciences. University of Bolton, Bolton, United Kingdom.

出版信息

Front Genet. 2018 Feb 7;9:21. doi: 10.3389/fgene.2018.00021. eCollection 2018.

DOI:10.3389/fgene.2018.00021
PMID:29469899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5808320/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e1c/5808320/075b983c78c0/fgene-09-00021-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e1c/5808320/075b983c78c0/fgene-09-00021-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e1c/5808320/075b983c78c0/fgene-09-00021-g0001.jpg

相似文献

1
Commentary: Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage.评论：基因组DNA中A·T到G·C的可编程碱基编辑，无需DNA切割。
Front Genet. 2018 Feb 7;9:21. doi: 10.3389/fgene.2018.00021. eCollection 2018.
2
Harnessing CRISPR-Cas systems for bacterial genome editing.利用 CRISPR-Cas 系统进行细菌基因组编辑。
Trends Microbiol. 2015 Apr;23(4):225-32. doi: 10.1016/j.tim.2015.01.008. Epub 2015 Feb 17.
3
Exploiting CRISPR-Cas immune systems for genome editing in bacteria.利用CRISPR-Cas免疫系统对细菌基因组进行编辑。
Curr Opin Biotechnol. 2016 Feb;37:61-68. doi: 10.1016/j.copbio.2015.10.003. Epub 2015 Nov 26.
4
Comparative analysis of lipid-mediated CRISPR-Cas9 genome editing techniques.脂质介导的 CRISPR-Cas9 基因组编辑技术的比较分析。
Cell Biol Int. 2018 Jul;42(7):849-858. doi: 10.1002/cbin.10952. Epub 2018 Mar 14.
5
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.通过蛋白质工程和蛋白质递送提高碱基编辑的 DNA 特异性和适用性。
Nat Commun. 2017 Jun 6;8:15790. doi: 10.1038/ncomms15790.
6
CRISPR-Cas immunity, DNA repair and genome stability.CRISPR-Cas 免疫、DNA 修复与基因组稳定性。
Biosci Rep. 2018 Sep 20;38(5). doi: 10.1042/BSR20180457. Print 2018 Oct 31.
7
Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting.通过临近 CRISPR 靶向实现靶向激活多种 CRISPR-Cas 系统用于哺乳动物基因组编辑。
Nat Commun. 2017 Apr 7;8:14958. doi: 10.1038/ncomms14958.
8
Gene Editing With TALEN and CRISPR/Cas in Rice.利用TALEN和CRISPR/Cas对水稻进行基因编辑
Prog Mol Biol Transl Sci. 2017;149:81-98. doi: 10.1016/bs.pmbts.2017.04.006. Epub 2017 May 24.
9
Applications of genome editing by programmable nucleases to the metabolic engineering of secondary metabolites.可编程核酸酶介导的基因组编辑在次生代谢物代谢工程中的应用。
J Biotechnol. 2017 Jan 10;241:50-60. doi: 10.1016/j.jbiotec.2016.11.009. Epub 2016 Nov 11.
10
CRISPR/Cas9-mediated correction of human genetic disease.CRISPR/Cas9介导的人类遗传疾病矫正
Sci China Life Sci. 2017 May;60(5):447-457. doi: 10.1007/s11427-017-9032-4. Epub 2017 May 3.

引用本文的文献

1
Optimization of in vivo delivery methods and their applications in seminiferous tubules of mice.体内递送方法的优化及其在小鼠生精小管中的应用。
BMC Biotechnol. 2025 Aug 12;25(1):83. doi: 10.1186/s12896-025-01021-0.
2
Mechanism of Genome Editing Tools and Their Application on Genetic Inheritance Disorders.基因组编辑工具的作用机制及其在遗传遗传性疾病中的应用
Glob Med Genet. 2024 Sep 16;11(4):319-329. doi: 10.1055/s-0044-1790558. eCollection 2024 Dec.
3
In Silico CRISPR-Cas-Mediated Base Editing Strategies for Early-Onset, Severe Cone-Rod Retinal Degeneration in Three Patients, including the Novel Variant c.2833G>A.

本文引用的文献

1
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.基因组DNA中A•T到G•C的可编程碱基编辑，无需DNA切割。
Nature. 2017 Nov 23;551(7681):464-471. doi: 10.1038/nature24644. Epub 2017 Oct 25.
2
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.提高碱基切除修复抑制和噬菌体 Mu Gam 蛋白产量可提高 C:G 到 T:A 碱基编辑器的效率和产物纯度。
Sci Adv. 2017 Aug 30;3(8):eaao4774. doi: 10.1126/sciadv.aao4774. eCollection 2017 Aug.
3
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
计算机模拟 CRISPR-Cas 介导的碱基编辑策略治疗三位患者的早发性、严重的 Cone-Rod 视网膜变性，包括新型变异 c.2833G>A。
Genes (Basel). 2024 May 15;15(5):625. doi: 10.3390/genes15050625.
4
Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions.用于研究宿主-肠道微生物组相互作用的以宿主为中心的分子工具的最新进展。
Front Microbiol. 2024 Mar 28;15:1335036. doi: 10.3389/fmicb.2024.1335036. eCollection 2024.
5
Application of CRISPR-Cas9 gene editing technology in basic research, diagnosis and treatment of colon cancer.CRISPR-Cas9 基因编辑技术在结肠癌基础研究、诊断与治疗中的应用。
Front Endocrinol (Lausanne). 2023 Mar 20;14:1148412. doi: 10.3389/fendo.2023.1148412. eCollection 2023.
6
Applications and Prospects of CRISPR/Cas9-Mediated Base Editing in Plant Breeding.CRISPR/Cas9介导的碱基编辑在植物育种中的应用与前景
Curr Issues Mol Biol. 2023 Jan 19;45(2):918-935. doi: 10.3390/cimb45020059.
7
The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19.基因编辑技术的最新进展及其在包括 COVID-19 在内的病毒感染和疾病中的应用。
Front Cell Infect Microbiol. 2022 Jun 9;12:869889. doi: 10.3389/fcimb.2022.869889. eCollection 2022.
8
Correction of Beta-Thalassemia IVS-II-654 Mutation in a Mouse Model Using Prime Editing.使用 Prime Editing 技术纠正小鼠模型中的β-地中海贫血 IVS-II-654 突变。
Int J Mol Sci. 2022 May 25;23(11):5948. doi: 10.3390/ijms23115948.
9
Reduced off-target effect of NG-BE4max by using NG-HiFi system.通过使用NG-HiFi系统降低NG-BE4max的脱靶效应。
Mol Ther Nucleic Acids. 2021 May 19;25:168-172. doi: 10.1016/j.omtn.2021.05.012. eCollection 2021 Sep 3.
10
Prime Editing: Genome Editing for Rare Genetic Diseases Without Double-Strand Breaks or Donor DNA.碱基编辑：无需双链断裂或供体DNA的罕见遗传病基因编辑
Front Genet. 2020 Jun 9;11:528. doi: 10.3389/fgene.2020.00528. eCollection 2020.
APOBEC3A 结合单链 DNA 的晶体结构揭示了胞嘧啶脱氨酶活性和特异性的结构基础。
Nat Commun. 2017 Apr 28;8:15024. doi: 10.1038/ncomms15024.
4
Delivery technologies for genome editing.基因组编辑的传递技术。
Nat Rev Drug Discov. 2017 Jun;16(6):387-399. doi: 10.1038/nrd.2016.280. Epub 2017 Mar 24.
5
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA.通过作用于RNA的腺苷脱氨酶对DNA/RNA杂交体进行DNA编辑。
Nucleic Acids Res. 2017 Apr 7;45(6):3369-3377. doi: 10.1093/nar/gkx050.
6
Genome-Editing Technologies: Principles and Applications.基因组编辑技术：原理与应用
Cold Spring Harb Perspect Biol. 2016 Dec 1;8(12):a023754. doi: 10.1101/cshperspect.a023754.
7
Applications of CRISPR technologies in research and beyond.CRISPR技术在研究及其他领域的应用。
Nat Biotechnol. 2016;34(9):933-941. doi: 10.1038/nbt.3659. Epub 2016 Sep 8.
8
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.一种治疗β-珠蛋白生成障碍性贫血的基因组编辑策略，该策略重现了与一种良性遗传疾病相关的突变。
Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15.
9
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.利用混合原核和脊椎动物适应性免疫系统进行靶向核苷酸编辑。
Science. 2016 Sep 16;353(6305). doi: 10.1126/science.aaf8729. Epub 2016 Aug 4.
10
The APOBEC Protein Family: United by Structure, Divergent in Function.载脂蛋白B编辑酶催化多肽（APOBEC）蛋白家族：结构统一，功能各异。
Trends Biochem Sci. 2016 Jul;41(7):578-594. doi: 10.1016/j.tibs.2016.05.001. Epub 2016 Jun 6.