School of Physics , University of Melbourne , Parkville , Victoria 3010 , Australia.
RMIT Microscopy and Microanalysis Facility (RMMF) , RMIT University , Melbourne , Victoria 3001 , Australia.
ACS Appl Mater Interfaces. 2018 Mar 14;10(10):8474-8484. doi: 10.1021/acsami.7b18596. Epub 2018 Mar 1.
Additive manufacturing using selective laser melted titanium (SLM-Ti) is used to create bespoke items across many diverse fields such as medicine, defense, and aerospace. Despite great progress in orthopedic implant applications, such as for "just in time" implants, significant challenges remain with regards to material osseointegration and the susceptibility to bacterial colonization on the implant. Here, we show that polycrystalline diamond coatings on these titanium samples can enhance biological scaffold interaction improving medical implant applicability. The highly conformable coating exhibited excellent bonding to the substrate. Relative to uncoated SLM-Ti, the diamond coated samples showed enhanced mammalian cell growth, enriched apatite deposition, and reduced microbial S. aureus activity. These results open new opportunities for novel coatings on SLM-Ti devices in general and especially show promise for improved biomedical implants.
使用选择性激光熔化钛（SLM-Ti）的增材制造技术被广泛应用于医学、国防和航空航天等多个不同领域，用于制造定制化产品。尽管在骨科植入物应用方面取得了很大进展，例如“准时”植入物，但在材料骨整合和植入物易受细菌定植方面仍存在重大挑战。在这里，我们表明，在这些钛样品上进行多晶金刚石涂层可以增强生物支架的相互作用，从而提高医疗植入物的适用性。这种高度适应性的涂层与基底表现出优异的结合力。与未涂层的 SLM-Ti 相比，金刚石涂层的样品显示出增强的哺乳动物细胞生长、丰富的磷灰石沉积和减少的金黄色葡萄球菌活性。这些结果为 SLM-Ti 器件的新型涂层开辟了新的机会，特别是为改善生物医学植入物带来了希望。
