Augustine Robin, Kalarikkal Nandakumar, Thomas Sabu
International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Priyadarshini Hills P. O., Kottayam, 686 560, Kerala, India.
School of Pure and Applied Physics, Mahatma Gandhi University, Priyadarshini Hills P. O., Kottayam, 686 560, Kerala, India.
Prog Biomater. 2014 Dec;3(2-4):103-113. doi: 10.1007/s40204-014-0030-y. Epub 2014 Nov 14.
This review gives a brief description on the skin and its essential functions, damages or injury which are common to the skin and the role of skin substitute to replace the functions of the skin soon after an injury. Skin substitutes have crucial role in the management of deep dermal and full thickness wounds. At present, there is no skin substitute in the market that can replace all the functions of skin 'and the research is still continuing for a better alternative. This review is an attempt to recollect and report the past efforts including skin grafting and recent trends like use of bioengineered smart skin substitutes in wound care. Incorporation functional moieties like antimicrobials and wound healing agents are also described.
本综述简要介绍了皮肤及其基本功能、皮肤常见的损伤，以及皮肤替代物在损伤后不久替代皮肤功能的作用。皮肤替代物在深度真皮和全层伤口的处理中起着关键作用。目前，市场上没有一种皮肤替代物能够替代皮肤的所有功能，相关研究仍在继续以寻求更好的替代品。本综述旨在回顾并报告过去的努力，包括皮肤移植以及伤口护理中使用生物工程智能皮肤替代物等最新趋势。文中还描述了抗菌剂和伤口愈合剂等功能性部分的应用。
