Hannequin D, Thibert A, Vaschalde Y
Presse Med. 1986 Sep 25;15(31):1575-6.
The vasogenic edema observed after irradiation of the brain constitutes a new and interesting model to study the anti-oedema properties of drugs. We have just completed a first pharmaco-clinical study of Ginkgo biloba extract with the dual purpose of assessing the feasibility of a therapeutic protocol and of deciding on simple and non-invasive criteria that would quantity cerebral oedema. The results of this pilot study have encouraged us to pursue our investigations under strict methodological conditions, in view of their therapeutic but also epidemiological interest.
脑部放疗后出现的血管源性水肿构成了一个研究药物抗水肿特性的全新且有趣的模型。我们刚刚完成了一项银杏叶提取物的首次临床药理学研究,其双重目的是评估治疗方案的可行性,并确定能够量化脑水肿的简单且非侵入性的标准。鉴于该初步研究结果在治疗和流行病学方面的意义,我们受到鼓舞,将在严格的方法学条件下继续开展研究。